POLYCYSTIC OVARY SYNDROME: PATHOPHYSIOLOGY, DIAGNOSTIC CRITERIA, REPRODUCTIVE CONSEQUENCES, AND EVIDENCE-BASED MANAGEMENT STRATEGIES IN MODERN GYNECOLOGY

Authors

  • Matqurbonova Dilnoza Ro‘zmatovna Asia International University

DOI:

https://doi.org/10.55640/

Keywords:

polycystic ovary syndrome, PCOS, hyperandrogenism, anovulatory infertility, insulin resistance, Rotterdam criteria, letrozole, metformin, ovarian stimulation, endometrial cancer risk, gynecology

Abstract

 Polycystic ovary syndrome (PCOS) is the most prevalent endocrine-metabolic disorder in women of reproductive age, affecting 8–13% of women globally and representing the leading cause of anovulatory infertility. Its heterogeneous clinical presentation—encompassing hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology—reflects a complex interplay of genetic susceptibility, neuroendocrine dysregulation, and metabolic disturbance. Despite its high prevalence and well-documented reproductive and metabolic sequelae, PCOS remains underdiagnosed and inadequately managed worldwide.

Downloads

Download data is not yet available.

References

1.Teede, H. J., Tay, C. T., Laven, J. J. E., Dokras, A., Moran, L. J., Piltonen, T. T., ... & Boivin, J. (2023). Recommendations from the 2023 International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Journal of Clinical Endocrinology & Metabolism, 108(10), 2447–2469. https://doi.org/10.1210/clinem/dgad463

2.Balen, A. H., Morley, L. C., Misso, M., Franks, S., Legro, R. S., Wijeyaratne, C. N., ... & Teede, H. J. (2016). The management of anovulatory infertility in women with polycystic ovary syndrome: An analysis of the evidence to support the development of global WHO guidance. Human Reproduction Update, 22(6), 687–708. https://doi.org/10.1093/humupd/dmw025

3.Goodarzi, M. O., Dumesic, D. A., Chazenbalk, G., & Azziz, R. (2011). Polycystic ovary syndrome: Etiology, pathogenesis and diagnosis. Nature Reviews Endocrinology, 7(4), 219–231. https://doi.org/10.1038/nrendo.2010.217

4.Diamanti-Kandarakis, E., & Dunaif, A. (2012). Insulin resistance and the polycystic ovary syndrome revisited: An update on mechanisms and implications. Endocrine Reviews, 33(6), 981–1030. https://doi.org/10.1210/er.2011-1034

5.Legro, R. S., Brzyski, R. G., Diamond, M. P., Coutifaris, C., Schlaff, W. D., Casson, P., ... & Zhang, H. (2014). Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. New England Journal of Medicine, 371(2), 119–129. https://doi.org/10.1056/NEJMoa1313517

6.Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., ... & Witchel, S. F. (2006). Positions statement: Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome. Journal of Clinical Endocrinology & Metabolism, 91(11), 4237–4245. https://doi.org/10.1210/jc.2006-0178

7.Wild, R. A., Carmina, E., Diamanti-Kandarakis, E., Dokras, A., Escobar-Morreale, H. F., Futterweit, W., ... & Dumesic, D. A. (2010). Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome. Journal of Clinical Endocrinology & Metabolism, 95(5), 2038–2049. https://doi.org/10.1210/jc.2009-2724

8.Palomba, S., de Wilde, M. A., Falbo, A., Koster, M. P. H., La Sala, G. B., & Fauser, B. C. J. M. (2015). Pregnancy complications in women with polycystic ovary syndrome. Human Reproduction Update, 21(5), 575–592. https://doi.org/10.1093/humupd/dmv029

Downloads

Published

2026-03-15

Issue

Vol. 5 No. 03 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

POLYCYSTIC OVARY SYNDROME: PATHOPHYSIOLOGY, DIAGNOSTIC CRITERIA, REPRODUCTIVE CONSEQUENCES, AND EVIDENCE-BASED MANAGEMENT STRATEGIES IN MODERN GYNECOLOGY. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(03), 824-833. https://doi.org/10.55640/

Similar Articles

1-10 of 503

You may also start an advanced similarity search for this article.