IMMUNE AND INFLAMMATORY MECHANISMS IN THE PATHOGENESIS OF POLYCYSTIC OVARY SYNDROME (PCOS): CURRENT EVIDENCE AND THERAPEUTIC PERSPECTIVES

Authors

  • Abdurashidova Xaitxon Bektemir qizi Andijan State Medical Institute. Assistant at the Department of 1-Obstetrics and Gynecology
  • Mutalipova Madinabonu Andijan State Medical Institute. Assistant at the Department of 1-Obstetrics and Gynecology
  • Abakulova Moxira Xamidjon qizi Andijan State Medical Institute. MD at the department of Oncology

DOI:

https://doi.org/10.55640/

Keywords:

Polycystic ovary syndrome; inflammation; immune response; NLRP3 inflammasome; granulosa cells; metabolic dysfunction.

Abstract

 Polycystic Ovary Syndrome (PCOS) is a complex endocrine and metabolic disorder affecting up to 15% of reproductive-aged women. Classical mechanisms such as hyperandrogenism and insulin resistance do not fully explain its heterogeneity. Recent research increasingly highlights immune dysregulation and chronic low-grade inflammation (LGCI) as central contributors to PCOS development. This review synthesizes recent findings (2022–2025) focusing on inflammatory cytokines, immune cell infiltration, ovarian microenvironment changes, and activation of molecular pathways including the NLRP3 inflammasome. We discuss how these immunometabolic changes interact with reproductive and endocrine dysfunction, and explore therapeutic strategies targeting inflammation. Future directions and research gaps are also addressed.

Downloads

Download data is not yet available.

References

1. Deng X, Chen Y, Xing X, Xu Y. Systematic low-grade chronic inflammation and intrinsic mechanisms in PCOS. Front Immunol. 2024.

2. Hui-Ying Q, Wen-Wu G. Low-grade inflammation in women with PCOS. J Int Reprod Health. 2024;43(1):48-52.

3. Orio F, Palomba S. Inflammatory mediators in PCOS. J Ovarian Res. 2025.

4. Shabbir S, Khurram E, Moorthi VS. Androgen–immune interactions in PCOS. J Transl Med. 2023;21:259.

5. Gu H et al. Immune cell infiltration in PCOS: bioinformatics analysis. BMC Pregnancy Childbirth. 2023;23:377.

6. Intra-ovarian inflammation and embryo quality in PCOS. Reprod Biol Endocrinol. 2024;22:11.

7. Zhang L et al. Transcriptomic inflammatory signatures in granulosa cells of women with PCOS. Genomics Inform. 2025.

8. The role of NLRP3 inflammasome in PCOS. Endocrine. 2024.

9. Caspase-1 and NLRP3 activity in granulosa cells in PCOS. Hum Reprod. 2024.

10. Inflammatory biomarkers and PCOS phenotypes. MEFSJ. 2023;28:33.

11. Immunometabolic mechanisms in PCOS. J Ovarian Res. 2025.

Downloads

Published

2025-12-04

Issue

Vol. 4 No. 11 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

IMMUNE AND INFLAMMATORY MECHANISMS IN THE PATHOGENESIS OF POLYCYSTIC OVARY SYNDROME (PCOS): CURRENT EVIDENCE AND THERAPEUTIC PERSPECTIVES. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(11), 148-150. https://doi.org/10.55640/

Similar Articles

1-10 of 402

You may also start an advanced similarity search for this article.