MORPHOLOGICAL AND MOLECULAR CHANGES IN OVARIAN TISSUE IN EXPERIMENTAL MODELS OF DISORDERS SIMILAR TO POLYCYSTIC OVARY SYNDROME

Authors

  • Ibragimova Ziyodakhon Jalolidinovna Assistant of the Department of Histology and Biology, Fergana Public Health Medical Institute

DOI:

https://doi.org/10.55640/

Keywords:

Polycystic ovary syndrome, experimental model, DHEA, letrozole model, ovarian morphology, molecular markers, folliculogenesis, inflammation, fibrosis.

Abstract

This scientific article provides an in-depth analysis of morphological and molecular changes in ovarian tissue based on experimental animal models of disorders similar to polycystic ovary syndrome (PCOS). Studies using models induced by dehydroepiandrosterone (DHEA), letrozole, and valproate demonstrate impaired folliculogenesis, stromal hypertrophy, collagen accumulation, angiogenic imbalance, and increased oxidative stress. Molecular analyses confirm reduced aromatase activity, an increased LH/FSH ratio, enhanced expression of insulin resistance markers, and activation of inflammatory and fibrotic processes mediated by the NF-κB and TGF-β signaling pathways. The article also evaluates the advantages and limitations of experimental models in investigating the pathogenesis of PCOS.

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References

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Published

2025-12-19

Issue

Vol. 4 No. 11 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

MORPHOLOGICAL AND MOLECULAR CHANGES IN OVARIAN TISSUE IN EXPERIMENTAL MODELS OF DISORDERS SIMILAR TO POLYCYSTIC OVARY SYNDROME. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(11), 2473-2476. https://doi.org/10.55640/

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