THE ROLE OF IMMUNO-BIOCHEMICAL MARKERS IN THE ACTIVE STAGE OF CHRONIC RHEUMATIC HEART DISEASE IN CHILDREN

Authors

  • Bobojonov Khurshid Jumaniyozovich Lecturer at the Department of Pre-Clinical Sciences Asia International University

DOI:

https://doi.org/10.5281/zenodo.20328942

Keywords:

heart disease

Abstract

Chronic rheumatic heart disease (CRHD) remains one of the most important acquired cardiovascular diseases in children and adolescents. The disease develops due to autoimmune inflammatory reactions after group A beta-hemolytic streptococcal infection and is characterized by progressive valvular damage, myocardial inflammation, and chronic cardiac insufficiency. The present study investigated serum levels of interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), and procalcitonin (PCT) in children with CRHD. Elevated TNF-α, CRP, and PCT together with reduced IL-10 were observed during active inflammatory stages. These biomarkers demonstrated high diagnostic and prognostic significance.

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References

1.Abbas A.K., Lichtman A.H., Pillai S. Cellular and Molecular Immunology. 10th ed. Elsevier; 2022.

2.Abdel-Massih RC, Mehta A, Abdelwahab S. Inflammatory cytokines in acute rheumatic carditis: a prospective controlled study. Pediatr Cardiol. 2010;31(7):1004–1010.

3.Altman D.G. Practical statistics for medical research. London: Chapman & Hall; 1991.

4.Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet. 1993;341(8844):515–518.

5.Assicot M. Procalcitonin as infection marker. Lancet. 1993;341:515–518.

6.Ayoub EM, Majeed HA. Acute rheumatic fever and post-streptococcal reactive arthritis. Clin Infect Dis. 2000;31(6):1484–1488.

7.Ayoub EM. Anti-streptococcal antibody response in rheumatic fever. J Pediatr. 2000;136(1):1–7.

8.Barash J, Mashiach E, Navon-Elkan P, et al. Differentiation of post-streptococcal reactive arthritis from acute rheumatic fever. J Pediatr. 2008;153(5):696–699.

9.Barst RJ, Gibbs JS, Ghofrani HA, et al. Updated evidence-based treatment algorithm in pulmonary arterial hypertension. J Am Coll Cardiol. 2009;54(1 Suppl):S78–84.

10.Beaton A, Okello E. Echocardiographic screening in rheumatic heart disease. Lancet Glob Health. 2017;5(7):e657–e666.

11.Beaton A., Okello E., Engelman D., et al. Echocardiography screening for rheumatic heart disease. Circulation. 2019;139(25):e115-e135.

12.Becker K.L., Nylen E.S., White J.C., Muller B., Snider R.H. Procalcitonin and the calcitonin gene family. Journal of Clinical Endocrinology & Metabolism. 2004;89(4):1512-1525.

13.Becker KL, Nylen ES, White JC, Müller B, Snider RH Jr. Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis. J Clin Endocrinol Metab. 2004;89(4):1512–1525.

14.Becker KL. Procalcitonin and inflammation. J Clin Endocrinol Metab. 2004;89(4):1512–1525.

15.Beutler B. Innate immunity: an overview. Mol Immunol. 2004;40(12):845–859.

16.Black S., Kushner I., Samols D. C-reactive protein. Journal of Biological Chemistry. 2004;279:48487-48490.

17.Bland EF, Jones TD. Rheumatic fever and rheumatic heart disease: a twenty year report on 1000 patients followed since childhood. Circulation. 1951;4(6):836–843.

18.Brennan FM, McInnes IB. Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest. 2008;118(11):3537–3545.

19.Carapetis J.R., Beaton A., Cunningham M.W., et al. Acute rheumatic fever and rheumatic heart disease. Nature Reviews Disease Primers. 2016;2:15084.

20.Carapetis JR, Beaton A, Cunningham MW, et al. Acute rheumatic fever and rheumatic heart disease. Nat Rev Dis Primers. 2016;2:15084.

21.Carapetis JR, Currie BJ, Mathews JD. C-reactive protein and streptococcal infection severity in children. Pediatr Infect Dis J. 2002;21(5):444–448.

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Published

2026-05-21

Issue

Vol. 5 No. 5 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

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Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

THE ROLE OF IMMUNO-BIOCHEMICAL MARKERS IN THE ACTIVE STAGE OF CHRONIC RHEUMATIC HEART DISEASE IN CHILDREN. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(5), 1547-1551. https://doi.org/10.5281/zenodo.20328942

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