ARTERIAL HYPOXIA AS A FACTOR AFFECTING THE COURSE OF CONGENITAL HEART DEFECTS IN CHILDREN
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Abstract
The most common forms of congenital heart defects (CHDs) in children include ventricular septal defect (VSD), atrial septal defect (ASD), and Tetralogy of Fallot. The natural course of these defects is often complicated by the development of severe complications caused by arterial hypoxia. The high mortality rate associated with septal heart defects in children is primarily due to progressive congestive heart failure and pulmonary hypertension. In patients with cyanotic CHDs, the leading pathogenetic factor is diffuse hypoxemia. Insufficient arterial blood oxygenation exacerbates the clinical manifestations of the defect and contributes to the development of cardiac arrhythmias, which may be regarded as an additional adverse prognostic factor in congenital heart disease.
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