ISCHEMIC HEART DISEASE: ETIOLOGY, CLINICAL MANIFESTATIONS, AND THERAPEUTIC APPROACHES

Authors

  • Abdurahimov Muhammadiyor Baxromjon og‘li, Ahmadjonov Nurolloh Ozodbek og‘li, Sultonmaxmudova Muslimaxon Xushnudbek qizi Kokand University, Andijan Branch Faculty of Medicine “General Medicine” Program, 1st Year, Groups 25–35
  • Ismoilov Alisher Polatjon og‘li Kokand University, Andijan Branch

DOI:

https://doi.org/10.55640/

Keywords:

Ischemic heart disease, coronary artery disease, atherosclerosis, myocardial infarction, chest pain, angina pectoris, risk factors, hypertension, cholesterol, diabetes, diagnosis, ECG, treatment, pharmacotherapy, angioplasty, coronary bypass, prevention, healthy lifestyle, cardiovascular health.

Abstract

Ischemic Heart Disease (IHD), also known as Coronary Artery Disease, is one of the most common and life-threatening cardiovascular disorders worldwide. It occurs when the blood flow to the heart muscle is reduced due to narrowing or blockage of the coronary arteries, usually caused by atherosclerosis. The main causes include unhealthy lifestyle habits, hypertension, high cholesterol levels, obesity, diabetes, and stress.
Typical symptoms of IHD are chest pain (angina pectoris), shortness of breath, fatigue, and in severe cases, myocardial infarction.
Diagnosis is based on clinical examination, electrocardiography (ECG), echocardiography, and coronary angiography. Treatment methods involve lifestyle modification, pharmacological therapy (such as antiplatelet agents, beta-blockers, and nitrates), and surgical procedures like angioplasty or coronary artery bypass grafting (CABG).
Early detection and timely treatment of ischemic heart disease are crucial for preventing complications and improving patients’ quality of life.

 

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References

1.Braunwald, E. (2015). Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine (10th ed.). Elsevier.

2.Libby, P., Bonow, R. O., Mann, D. L., & Zipes, D. P. (2018). Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine (11th ed.). Elsevier.

3.Yusuf, S., Reddy, S., Ôunpuu, S., & Anand, S. (2001). Global burden of cardiovascular diseases: Part I: General considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation, 104(22), 2746-2753.

4.World Health Organization. (2021). Cardiovascular diseases (CVDs). Retrieved from https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)

5.Fuster, V., & Alexander, R. W. (2004). Hurst’s The Heart (11th ed.). McGraw-Hill.

6.Cannon, C. P., & Braunwald, E. (2009). Acute coronary syndromes. New England Journal of Medicine, 360(24), 2481-2494.

7.National Heart, Lung, and Blood Institute. (2022). Coronary Artery Disease. Retrieved from https://www.nhlbi.nih.gov/health-topics/coronary-artery-disease

8.American Heart Association. (2023). Understanding Ischemic Heart Disease. Retrieved from https://www.heart.org/en/health-topics/ischemic-heart-disease

9.Libby, P. (2002). Inflammation in atherosclerosis. Nature, 420(6917), 868-874.

10.Khot, U. N., & Khot, M. B. (2003). Clinical presentation and diagnosis of ischemic heart disease. Circulation, 108(4), 495-500.

11.Antman, E. M., & Loscalzo, J. (2012). Ischemic heart disease: Pathophysiology and treatment. In J. Loscalzo (Ed.), Harrison’s Principles of Internal Medicine (18th ed., pp. 1545-1557). McGraw-Hill.

12.Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., ... & INTERHEART Study Investigators. (2004). Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study. The Lancet, 364(9438), 937-952.

13.Cannon, C. P., & Braunwald, E. (2013). Management of acute coronary syndromes. Circulation, 127(6), 666-676.

14.Topol, E. J., & Califf, R. M. (2010). Textbook of Cardiovascular Medicine (3rd ed.). Lippincott Williams & Wilkins.

15.James, P. T., Leach, R., Kalamara, E., & Shayeghi, M. (2001). The worldwide obesity epidemic. Obesity Research, 9(S11), 228S-233S.

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Published

2025-10-27

Issue

Vol. 4 No. 9 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

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Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

ISCHEMIC HEART DISEASE: ETIOLOGY, CLINICAL MANIFESTATIONS, AND THERAPEUTIC APPROACHES. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(9), 1205-1208. https://doi.org/10.55640/

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