TYPE 2 DIABETES MELLITUS: GLOBAL EPIDEMIOLOGICAL TRENDS, MOLECULAR MECHANISMS AND RISK FACTORS WITH SPECIAL REFERENCE TO UZBEKISTAN

Authors

  • Pazliddinov A.V.,Nusratullayev I.R,Pazliddinova D.R. Head of the department pharmaceutical science Andijan state medical institute,doctor endocrinologist at Republican Scientific and Practical Medical Center of Endocrinology,Master student at Andijan state medical institute

DOI:

https://doi.org/10.5281/zenodo.20065907

Keywords:

Pregnancy-related

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from insulin resistance, impaired insulin secretion, or a combination of both mechanisms. It represents approximately 90–95% of all diabetes cases and is associated with a wide spectrum of microvascular and macrovascular complications that significantly increase morbidity and mortality worldwide. Due to its progressive nature and multisystem involvement, T2DM has become one of the most pressing global public health challenges of the 21st century.

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References

1.International Diabetes Federation (2021) IDF Diabetes Atlas. 10th edn. Brussels: IDF.

2.American Diabetes Association (2025) ‘Standards of Care in Diabetes—2025’, Diabetes Care, 48(Suppl 1), pp. S1–S350.

3.Zheng, Y., Ley, S.H. and Hu, F.B. (2018) ‘Global aetiology and epidemiology of type 2 diabetes mellitus and its complications’, Nature Reviews Endocrinology, 14(2), pp. 88–98.

4.DeFronzo, R.A., Ferrannini, E., Groop, L. et al. (2015) ‘Type 2 diabetes mellitus’, Nature Reviews Disease Primers, 1, 15019.

5.Rehman, K. and Akash, M.S.H. (2017) ‘Mechanisms of inflammatory responses and development of insulin resistance’, Mediators of Inflammation, 2017, 1–18.

6.Rolo, A.P. and Palmeira, C.M. (2006) ‘Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress’, Toxicology and Applied Pharmacology, 212(2), pp. 167–178.

7.Lowell, B.B. and Shulman, G.I. (2005) ‘Mitochondrial dysfunction and type 2 diabetes’, Science, 307(5708), pp. 384–387.

8.Lee, C. et al. (2015) ‘MOTS-c: a mitochondrial-derived peptide regulating glucose metabolism’, Cell Metabolism, 21(3), pp. 443–454.

9.Petersen, M.C. and Shulman, G.I. (2018) ‘Mechanisms of insulin action and insulin resistance’, Physiological Reviews, 98(4), pp. 2133–2223.

10.World Health Organization (2023) Global Report on Diabetes. Geneva: WHO.

11.Atlas, S.J. et al. (2020) ‘Global burden of diabetes’, The Lancet, 395(10225), pp. 1075–1088.

12.Hu, F.B. (2011) ‘Globalization of diabetes: the role of diet, lifestyle and genes’, Diabetes Care, 34(6), pp. 1249–1257.

13.Pan, A. et al. (2015) ‘Smoking and risk of type 2 diabetes: meta-analysis’, JAMA, 314(15), pp. 1519–1528.

14.Bellou, V. et al. (2018) ‘Risk factors for type 2 diabetes mellitus’, BMC Endocrine Disorders, 18(1), pp. 1–12.

15.Bao, W. et al. (2018) ‘Gestational diabetes and risk of type 2 diabetes’, Diabetologia, 61(2), pp. 351–358.

16.American College of Obstetricians and Gynecologists (2021) ‘Gestational diabetes mellitus’, ACOG Practice Bulletin, 190, pp. 1–25.

17.Kautzky-Willer, A. et al. (2016) ‘Gestational diabetes and long-term metabolic risk’, Diabetologia, 59(7), pp. 1371–1379.

18.Cho, N.H. et al. (2018) ‘IDF Diabetes Atlas: global estimates of diabetes prevalence’, Diabetes Research and Clinical Practice, 138, pp. 271–281.

19.Zhang, P. et al. (2010) ‘Global health burden of diabetes’, Diabetes Care, 33(8), pp. 1859–1864.

20.Karimov, S. et al. (2022) ‘Diabetes mellitus in Uzbekistan: epidemiological trends and healthcare challenges’, Central Asian Journal of Medical Sciences, 8(2), pp. 45–53.

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Published

2026-05-07

Issue

Vol. 5 No. 5 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

TYPE 2 DIABETES MELLITUS: GLOBAL EPIDEMIOLOGICAL TRENDS, MOLECULAR MECHANISMS AND RISK FACTORS WITH SPECIAL REFERENCE TO UZBEKISTAN. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(5), 462-469. https://doi.org/10.5281/zenodo.20065907

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