THE EFFECT OF DIBUNOL ON THE LIPID CONTENT IN THE BLOOD SERUM OF RABBITS WITH EXPERIMENTAL ATHEROSCLEROSIS

Authors

  • T. Saydullaev Andijan State Medical Institute

DOI:

https://doi.org/10.55640/

Keywords:

: dibunol, atherosclerosis, lipid profile, serum cholesterol, antioxidant, rabbits.

Abstract

This study investigates the influence of dibunol (also known as ionol or butylated hydroxytoluene, BHT), an antioxidant compound, on the lipid profile of rabbits with experimentally induced atherosclerosis. Using a high-cholesterol diet to simulate hyperlipidemia and plaque formation, the experiment evaluates how dibunol administration alters key lipid parameters, including total cholesterol, triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels in blood serum. The findings suggest that dibunol has a lipid-modulating effect and may contribute to the prevention or attenuation of atherosclerotic changes through its antioxidant properties.

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References

1.Steinberg, D. (2012). Atherogenesis in perspective: Hypercholesterolemia and inflammation as partners in crime. Nature Medicine, 8(11), 1211–1217.

2.Mikhailidis, D. P., & Elisaf, M. (2018). Lipid-lowering drugs and antioxidant therapy in atherosclerosis. Current Pharmaceutical Design, 14(3), 238–248.

3.Pokrovsky, S. N., & Markin, A. A. (2013). Lipid metabolism and antioxidants. Moscow: Meditsina.

4.Vlasov, A. P., et al. (2015). The effect of dibunol on lipid peroxidation in rabbits with experimental atherosclerosis. Bulletin of Experimental Biology and Medicine, 119(4), 377–380.

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Published

2025-05-18

Issue

Vol. 4 No. 4 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

THE EFFECT OF DIBUNOL ON THE LIPID CONTENT IN THE BLOOD SERUM OF RABBITS WITH EXPERIMENTAL ATHEROSCLEROSIS. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(4), 480-481. https://doi.org/10.55640/

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