FUNCTIONAL ACTIVITY OF THE THYROID GLAND IN STRESS CONDITIONS

Authors

  • Komiljonova Oygul Olimjonovna Department of Fundamental Medicine Asia International University

DOI:

https://doi.org/10.55640/

Keywords:

stress, glucocorticoids, thyroid gland, thyroid hormones, iodine uptake and organification, deiodinases.

Abstract

 An analytical review was conducted of studies investigating the effects of acute and chronic stress on thyroid gland metabolism. Particular attention is given to the influence of stress and, specifically, glucocorticoids on thyroid status. The discussion encompasses stress-related alterations in iodine uptake, oxidation, and organification within thyrocytes, as well as changes in the peripheral metabolism of thyroid hormones, including their storage, transport, and tissue-specific deiodinase activity.The role of stress in the development of thyroid disorders is also examined, with emphasis on functional alterations of the thyroid gland associated with dysregulation of the hypothalamic–pituitary–adrenal axis. Emerging evidence suggests consistent patterns of thyroid dysfunction in conditions involving impaired pituitary–adrenal system activity.

Mechanisms underlying stress-induced thyroid impairment remain an important area for further investigation, particularly given the significant systemic consequences associated even with subclinical forms of thyroid insufficiency.

Downloads

Download data is not yet available.

References

1.Romeo RD, Karatsoreos IN, Ali FS, McEwen BS. Stress. 2007;10:101–106.

2.Bagnasco M, Bossert I, Pesce G. Neuroimmunomodulation. 2006;13:309–317.

3.Kakourou T, Karachristou K, Chrousos G. Eur Acad Dermatol Venereol. 2007;21:56–59.

4.Maralcan G, Erkol H, Erkol Z, Yanar F, Plevin R. Ulus Travma Acil Cerrahi Derg. 2008;14:96–102.

5.Drozd VM, Mityukova N, Leonova TA, Lushchik ML, Platonova TYu. Vestsi Nats Akad Navuk Belarusi. 2006;2:103–112.

6.Delange F. Thyroid International. 2002;5:3–18.

7.Poncin S, Gérard AC, Boucquey M, Senou M, Calderon PB, Knoops B, Lengelé B, Many MC, Colin IM. Endocrinology. 2008;149:424–433.

8.Romani JD. C R Seances Soc Biol Fil. 1952;146:344–348.

9.Badrick FE, Brimblecombe RW, Reiss JM, Reiss M. J Endocrinol. 1954;11:305–313.

10.Williams RH, Jaffe H, Kemp C. Am J Physiol. 1949;159:291–297.

11.Belyakova EI, Mendzheritsky AM. Ross Fiziol Zh Im IM Sechenova. 2005;91:611–615.

12.Armario A, Castellanos JM, Balasch J. Horm Res. 1984;20:241–245.

13.Helmreich DL, Parfitt DB, Lu XY, Akil H, Watson SJ. Neuroendocrinology. 2005;81:183–192.

14.Langer P, Vigas M. Acta Endocrinol (Copenh). 1983;104:443–449.

15.Bianco AC, Nunes MT, Hell NS, Maciel RM. Endocrinology. 1987;120:1033–1038.

Downloads

Published

2026-02-19

Issue

Vol. 5 No. 02 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

FUNCTIONAL ACTIVITY OF THE THYROID GLAND IN STRESS CONDITIONS. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(02), 1578-1586. https://doi.org/10.55640/

Similar Articles

1-10 of 230

You may also start an advanced similarity search for this article.