HYPOTHALAMIC-PITUITARY NEUROSECRETORY SYSTEM UNDER THE INFLUENCE OF EXTREME FACTORS.

Authors

  • Shukurova Dilorom Bakhodirovna,Khamraeva Shakhzoda Shodievna assistant of the Department of Physiology, Samarkand State Medical University, Uzbekistan,student of Samarkand State Medical University

DOI:

https://doi.org/10.55640/

Keywords:

hypothalamus, pituitary gland, stress, adaptation, hormones, extreme factors, neurosecretion, cortisol, adrenocorticotropic hormone, thyroid-stimulating hormone, hypoxia, metabolism, endocrine regulation, physiological adaptation, homeostasis.

Abstract

The hypothalamic-pituitary neurosecretory system plays a key role in regulating the body's adaptive processes, ensuring a balance between neural and endocrine regulation. Extreme factors such as stress, physical exertion, temperature changes, hypoxia, and toxic environmental exposure significantly affect its functioning. In response to stressors, the system activates neuroendocrine regulation mechanisms aimed at maintaining homeostasis and adapting the body to adverse conditions. Imbalance in the functioning of this system can lead to metabolic disorders, immune dysfunction, and the development of pathological conditions such as chronic stress, depression, and endocrine disorders. This article examines the main adaptation mechanisms of the hypothalamic-pituitary system to extreme conditions, the influence of various factors on hormone secretion, as well as the possible consequences of prolonged dysregulation of this system. Studying these processes will help develop effective strategies for correcting and preventing stress-induced disorders.

Downloads

Download data is not yet available.

References

1.Sapolsky R.M., Romero L.M., Munck A.U. (2000). How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocrine Reviews, 21(1), 55-89. Kalsbeek A., Palm I.F., La Fleur S.E., et al. (2012). SCN outputs and the hypothalamic balance of life. Journal of Biological Rhythms, 27(4), 257-267.

2. Chrousos G.P. (2009). Stress and disorders of the stress system. Nature Reviews Endocrinology, 5(7), 374-381.

3. Selye H. (1976). The Stress of Life. McGraw-Hill.

4. McEwen B.S. (2007). Physiology and neurobiology of stress and adaptation: Central role of the brain. Physiological Reviews, 87(3), 873-904.

5. Rivier C., Vale W. (1984). Influence of corticotropin-releasing factor on reproductive functions in the rat. Science, 224(4648), 889-891.

6. Herman J.P., Cullinan W.E. (1997). Neurocircuitry of stress: Central control of the hypothalamo-pituitary-adrenocortical axis. Trends in Neurosciences, 20(2), 78-84.

Downloads

Published

2025-03-27

Issue

Vol. 4 No. 2 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

HYPOTHALAMIC-PITUITARY NEUROSECRETORY SYSTEM UNDER THE INFLUENCE OF EXTREME FACTORS. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(2), 389-394. https://doi.org/10.55640/

Similar Articles

1-10 of 1084

You may also start an advanced similarity search for this article.