HYPOTHALAMIC-PITUITARY NEUROSECRETORY SYSTEM UNDER THE INFLUENCE OF EXTREME FACTORS.

Main Article Content

Shukurova Dilorom Bakhodirovna,Khamraeva Shakhzoda Shodievna

Abstract

The hypothalamic-pituitary neurosecretory system plays a key role in regulating the body's adaptive processes, ensuring a balance between neural and endocrine regulation. Extreme factors such as stress, physical exertion, temperature changes, hypoxia, and toxic environmental exposure significantly affect its functioning. In response to stressors, the system activates neuroendocrine regulation mechanisms aimed at maintaining homeostasis and adapting the body to adverse conditions. Imbalance in the functioning of this system can lead to metabolic disorders, immune dysfunction, and the development of pathological conditions such as chronic stress, depression, and endocrine disorders. This article examines the main adaptation mechanisms of the hypothalamic-pituitary system to extreme conditions, the influence of various factors on hormone secretion, as well as the possible consequences of prolonged dysregulation of this system. Studying these processes will help develop effective strategies for correcting and preventing stress-induced disorders.

Downloads

Download data is not yet available.

Article Details

Section

Articles

How to Cite

HYPOTHALAMIC-PITUITARY NEUROSECRETORY SYSTEM UNDER THE INFLUENCE OF EXTREME FACTORS. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(2), 389-394. https://doi.org/10.55640/

References

1.Sapolsky R.M., Romero L.M., Munck A.U. (2000). How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocrine Reviews, 21(1), 55-89. Kalsbeek A., Palm I.F., La Fleur S.E., et al. (2012). SCN outputs and the hypothalamic balance of life. Journal of Biological Rhythms, 27(4), 257-267.

2. Chrousos G.P. (2009). Stress and disorders of the stress system. Nature Reviews Endocrinology, 5(7), 374-381.

3. Selye H. (1976). The Stress of Life. McGraw-Hill.

4. McEwen B.S. (2007). Physiology and neurobiology of stress and adaptation: Central role of the brain. Physiological Reviews, 87(3), 873-904.

5. Rivier C., Vale W. (1984). Influence of corticotropin-releasing factor on reproductive functions in the rat. Science, 224(4648), 889-891.

6. Herman J.P., Cullinan W.E. (1997). Neurocircuitry of stress: Central control of the hypothalamo-pituitary-adrenocortical axis. Trends in Neurosciences, 20(2), 78-84.

Similar Articles

You may also start an advanced similarity search for this article.