LIPID PEROXIDATION AND ITS ROLE IN THE PATHOGENESIS OF CELL DAMAGE

Authors

  • Shukurlayeva Mehriniso Khayrullo kizi, Safarova Zariniso Tashkent State Medical University

DOI:

https://doi.org/10.55640/

Keywords:

Lipid peroxidation, Free radicals, Oxidative stress, Cell damage, Antioxidants, Membrane dysfunction, Pathogenesis.

Abstract

This article discusses the process of lipid peroxidation (LPO) and its role in the pathogenesis of cell damage. Lipid peroxidation is a complex chain reaction that occurs as a result of the oxidation of polyunsaturated fatty acids, one of the main components of biological membranes, under the influence of free radicals. This process leads to negative consequences such as disruption of cell membrane integrity, disruption of ion exchange, mitochondrial dysfunction, formation of cytotoxic aldehydes, and increased oxidative stress. Increased LPO plays an important role in the pathogenesis of cardiovascular diseases, neurodegenerative diseases, atherosclerosis, diabetes, inflammatory processes, and cancer. The article also analyzes the protective mechanisms of the antioxidant system, their function in limiting LPO, and their therapeutic significance.

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References

1.Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine. Oxford University Press, 2015.

2.Esterbauer H., Cheeseman K.H. “Lipid peroxidation: mechanisms and chemical aspects.” Free Radical Biology & Medicine, 1990.

3.Droge W. “Free radicals in the physiological control of cell function.” Physiological Reviews, 2002.

4.Betteridge D.J. “What is oxidative stress?” Metabolism, 2000.

5.Birben E. et al. “Oxidative stress and antioxidant capacity.” World Allergy Organization Journal, 2012.

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Published

2025-12-25

Issue

Vol. 4 No. 11 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

LIPID PEROXIDATION AND ITS ROLE IN THE PATHOGENESIS OF CELL DAMAGE. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(11), 2961-2965. https://doi.org/10.55640/

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