LIPID PEROXIDATION AND ITS ROLE IN THE PATHOGENESIS OF CELL DAMAGE
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Abstract
This article discusses the process of lipid peroxidation (LPO) and its role in the pathogenesis of cell damage. Lipid peroxidation is a complex chain reaction that occurs as a result of the oxidation of polyunsaturated fatty acids, one of the main components of biological membranes, under the influence of free radicals. This process leads to negative consequences such as disruption of cell membrane integrity, disruption of ion exchange, mitochondrial dysfunction, formation of cytotoxic aldehydes, and increased oxidative stress. Increased LPO plays an important role in the pathogenesis of cardiovascular diseases, neurodegenerative diseases, atherosclerosis, diabetes, inflammatory processes, and cancer. The article also analyzes the protective mechanisms of the antioxidant system, their function in limiting LPO, and their therapeutic significance.
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1.Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine. Oxford University Press, 2015.
2.Esterbauer H., Cheeseman K.H. “Lipid peroxidation: mechanisms and chemical aspects.” Free Radical Biology & Medicine, 1990.
3.Droge W. “Free radicals in the physiological control of cell function.” Physiological Reviews, 2002.
4.Betteridge D.J. “What is oxidative stress?” Metabolism, 2000.
5.Birben E. et al. “Oxidative stress and antioxidant capacity.” World Allergy Organization Journal, 2012.