PHARMACOLOGICAL MECHANISMS OF GLYCEMIC CONTROL AND CLINICAL-EXPERIMENTAL EFFICACY OF THE HERBAL PHYTOCOMPLEX “ANTIDIABETOL”

Authors

  • Islomova Sumbula Abdisami kizi Tashkent State Medical University

DOI:

https://doi.org/10.55640/

Keywords:

Antidiabetol; type 2 diabetes mellitus; hyperglycemia; phytotherapy; hypoglycemic activity; toxicology; β-cell regeneration; oxidative stress; lipid metabolism.

Abstract

This study evaluates the hypoglycemic activity and safety of the herbal phytocomplex “Antidiabetol.” Using alimentary, adrenaline-induced, and alloxan-induced hyperglycemia models, the formulation demonstrated significant glucose-lowering effects and improvements in lipid metabolism. Toxicological tests confirmed the absence of acute, cumulative, allergenic, and cardiotoxic effects. The results indicate that “Antidiabetol” is a safe and promising phytotherapeutic agent for type 2 diabetes management.

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References

1.Islomova, S. A. (2025). Antidiabetol yig‘masining farmakologik xususiyatlarini o‘rganish [Master’s thesis, Tashkent Pharmaceutical Institute].

2.International Diabetes Federation. (2023). IDF Diabetes Atlas (10th ed.). Brussels, Belgium: IDF. https://idf.org

3.Pari, L., & Saravanan, R. (2010). Antidiabetic effects of herbal poly-formulations: Mechanisms and clinical perspectives. Journal of Ethnopharmacology, 129(1), 1–13. https://doi.org/10.1016/j.jep.2010.03.041

4.Velmurugan, C., & Bhargava, A. (2013). Evaluation of hypoglycemic and hypolipidemic activity of Pyrus communis extract in dexamethasone-induced diabetic rats. Phytomedicine, 20(1), 1–7. https://doi.org/10.1016/j.phymed.2012.08.011

5.Suhendi, A., Muhtadi, M., & Rasyid, F. N. (2021). Hypoglycemic potential of combined extracts of Channa striata and Momordica charantia: A clinical assessment. Journal of Herbal Medicine, 28, 100437. https://doi.org/10.1016/j.hermed.2021.100437

6.Kifle, Z. D., & Belayneh, Y. M. (2022). Antidiabetic and antihyperlipidemic activities of Hagenia abyssinica leaf extract in STZ-induced diabetic mice. BMC Complementary Medicine and Therapies, 22(1), 241. https://doi.org/10.1186/s12906-022-03642-z

7.Njagi, J. M., Ngugi, M. P., & Mburu, D. N. (2015). Hypoglycemic effects of aqueous leaf extract of Helichrysum odoratissimum in alloxan-induced diabetic mice. Journal of Diabetes Research, 2015, 1–7. https://doi.org/10.1155/2015/126584

8.Rao, R. M., Salem, F., & Gleason-Jordan, I. (2018). Antidiabetic potential of “Pancreas Tonic” in alloxan-induced diabetic rats: β-cell protective effects. Phytotherapy Research, 32(4), 621–629. https://doi.org/10.1002/ptr.5992

9.Dekhkambayeva , Z., Nishanova, Y., & Toshboeva , N. (2025). IMPROVING EDUCATIONAL EFFECTIVENESS IN TEACHING RADIONUCLIDE-NEGATIVE BREAST CANCER THROUGH COMPREHENSIVE RADIODIAGNOSIS. International Journal of Medical Sciences, 1(4), 108–112. Retrieved from https://inlibrary.uz/index.php/ijms/article/view/97163

10.Dekhkambayeva, Z. ., Rahimova, M. ., & Panabaeva , N. . (2025). EFFECTIVNES OF INTENSIFICATION AND ACCELERATION TECHNOLOGIES IN TEACHING CHRONIC HEART FAILURE TO STUDENTS. International Journal of Medical Sciences, 1(4), 28+32. Retrieved from

11.ANALYSIS OF CONCEPTS OF DEVELOPING THE CREATIVE ABILITY OF STUDENTS IN HIGHER EDUCATIONAL INSTITUTIONS. (2025). EduVision: Journal of Innovations in Pedagogy and Educational Advancements, 1(2), 292-296. https://brightmindpublishing.com/index.php/ev/article/view/134

12.Zulfiya, D. (2023). MAKTABGACHA TALIM-TARBIYANI TASHKIL ETISHDA KOMPETENSIYAVIY YONDASHUVNING DOLZARBLIGI. IQRO INDEXING, 1(1), 36-40.

13.Zulfiya, D. "MAKTABGACHA TALIM-TARBIYANI TASHKIL ETISHDA KOMPETENSIYAVIY YONDASHUVNING DOLZARBLIGI." IQRO INDEXING 1.1 (2023): 36-40.

14.Abubakirovna, Dekhkambayeva Zulfia. "SOCIAL ADAPTATION OF CHILDREN IN KINDERGARTEN OF PRESCHOOL AGE." Web of Humanities: Journal of Social Science and Humanitarian Research 1.9 (2023): 76-79

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Published

2025-12-09

Issue

Vol. 4 No. 11 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

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Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

PHARMACOLOGICAL MECHANISMS OF GLYCEMIC CONTROL AND CLINICAL-EXPERIMENTAL EFFICACY OF THE HERBAL PHYTOCOMPLEX “ANTIDIABETOL”. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(11), 711-715. https://doi.org/10.55640/

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