CUTTING-EDGE BIOMEDICAL STRATEGIES IN DENTAL IMPLANTOLOGY: EXPLOITING STEM CELL POTENTIAL FOR SUPERIOR OSSEOINTEGRATION AND MULTIDIMENSIONAL TISSUE REGENERATION
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Abstract
Background: Successful dental implantation depends on effective osseointegration and stable peri-implant tissue regeneration. Stem cell–based regenerative strategies have shown promise in enhancing bone formation and implant integration.
Objective: This study aimed to evaluate the effectiveness of autologous stem cells derived from peripheral blood and adipose tissue in promoting osseointegration and bone regeneration in patients undergoing dental implantation in Uzbekistan.
Materials and Methods: Twenty patients (10 men and 10 women, aged 35–47 years) received implants in the upper and lower jaws. Stem cells were isolated from peripheral blood and adipose tissue, combined into a single regenerative mixture, and applied to the implant surfaces before insertion. Patients were monitored over six months for clinical healing, implant stability, and radiographic bone regeneration.
Results: The application of stem cell–enriched coatings demonstrated enhanced early soft tissue healing, improved implant stability, and accelerated bone formation. Platelet-derived growth and inhibitory factors contributed to regulated bone growth, preventing excessive calcification.
Conclusions: The combined use of autologous stem cells and platelet-derived factors represents a safe and effective approach to promoting osseointegration and multidimensional tissue regeneration in dental implantology. This method offers a novel, biologically driven strategy with practical relevance for clinical practice in Uzbekistan.
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