STEM CELLS IN TISSUE REGENERATION: HISTOLOGICAL PERSPECTIVES AND CLINICAL APPLICATIONS
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Abstract
Stem cells play a pivotal role in tissue regeneration due to their unique ability to self-renew and differentiate into various specialized cell types. Histological studies provide essential insights into the morphology, behavior, and integration of stem cells within different tissue environments. This paper reviews the histological characteristics of stem cells and their niches, emphasizing their regenerative potential in organs such as the heart, liver, skin, and nervous system. Additionally, the clinical applications of stem cell therapies in regenerative medicine are discussed, highlighting current advances, challenges, and future prospects. Understanding the histological basis of stem cell function is crucial for developing effective treatments for degenerative diseases and tissue injuries.
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1.Alvarez-Buylla, A., & Lim, D. A. (2004). For the long run: maintaining germinal niches in the adult brain. Neuron, 41(5), 683-686.
2.Morrison, S. J., & Spradling, A. C. (2008). Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell, 132(4), 598-611.
3.Pittenger, M. F., Mackay, A. M., Beck, S. C., et al. (1999). Multilineage potential of adult human mesenchymal stem cells. Science, 284(5411), 143-147.
4.Dimmeler, S., & Leri, A. (2008). Aging and disease as modifiers of efficacy of cell therapy. Circulation Research, 102(11), 1319-1330.
5.Trounson, A., & McDonald, C. (2015). Stem cell therapies in clinical trials: progress and challenges. Cell Stem Cell, 17(1), 11-22.
6.Li, L., & Xie, T. (2005). Stem cell niche: structure and function. Annual Review of Cell and Developmental Biology, 21, 605-631.
7.Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126(4), 663-676.
8.Bianco, P., & Robey, P. G. (2001). Stem cells in tissue engineering. Nature, 414(6859), 118-121.
9.Caplan, A. I. (2007). Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Journal of Cellular Physiology, 213(2), 341-347.
10.Gage, F. H. (2000). Mammalian neural stem cells. Science, 287(5457), 1433-1438.