HISTOLOGICAL CHANGES LARYNGEAL TISSUES INDUCED BY CYPERMETHRIN EXPOSURE
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Abstract
Objective: To investigate the histomorphological alterations in the laryngeal tissues of rabbits (Oryctolagus cuniculus) following exposure to cypermethrin (CYP), a synthetic pyrethroid insecticide.
Methods: Eighteen adult male New Zealand White rabbits were used. Thirteen animals formed the experimental group, subjected to cypermethrin aerosol exposure for one month. Five rabbits served as the control group. Laryngeal tissues were processed, stained with Hematoxylin and Eosin (H&E) and Masson's Trichrome, and examined using light microscopy. The degree of tissue damage was evaluated using a semi-quantitative scoring method.
Results: The experimental group exhibited pronounced destructive and proliferative changes: hyperplasia and desquamation of the basal epithelial layer, severe edema and a dense inflammatory infiltrate in the submucosa, reduced secretory activity, and vacuolization of glandular cells. Significantly, focal degradation of chondrocytes and destruction of the cartilage matrix were observed. Isolated areas of epithelial metaplasia, where normal stratified squamous epithelium was replaced by columnar epithelium, were also identified.
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References
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