MORPHOLOGICAL FEATURES OF THE EFFECT OF PESTICIDES ON TRACHEOBRONCHIAL LYMPH NODES

Authors

  • Sh. B. Qo‘chqorov Researcher (Investigator) in Morphology at the Fergana Medical Institute of Public Health.

DOI:

https://doi.org/10.55640/

Abstract

This study investigates the profound morphological and systemic changes induced in laboratory rabbits by chronic aerosol exposure to the organophosphate pesticide Chlorpyrifos (CPF). The objective was to characterize the regional immunotoxicity by analyzing the tracheobronchial lymph nodes (TBLNs) and lung tissue. The intoxication, administered as an aerosol (1:50 dilution, twice every three days for four months), resulted in severe negative systemic effects, including substantial body weight loss (up to 20% decline) and marked clinical signs of poisoning. Pathohistological analysis revealed significant pulmonary pathology (edema, hypertrophy of Club/Clara cells, peribronchial inflammation) and distinct structural shifts in the TBLNs. Key changes in TBLNs included cortical widening, lymphoid follicular dystrophy, a narrowed medulla, and severe accumulation of free macrophages in the medullary sinusoids. These findings establish that chronic CPF aerosol exposure exerts a high degree of toxicity on both the respiratory and immune systems, critically impairing regional immune competence.

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References

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Published

2025-12-15

Issue

Vol. 4 No. 11 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

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Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

MORPHOLOGICAL FEATURES OF THE EFFECT OF PESTICIDES ON TRACHEOBRONCHIAL LYMPH NODES. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(11), 1920-1923. https://doi.org/10.55640/