VITAMIN D STATUS IN PATIENTS WITH PREDIABETES AND TYPE 2 DIABETES MELLITUS DEPENDING ON THE DISTRICTS OF ANDIJAN REGION
Article Sidebar
Main Article Content
Abstract
This article examines the prevalence of vitamin D, zinc, and calcium deficiencies among patients with disorders of carbohydrate metabolism (prediabetes, impaired glucose tolerance, type 2 diabetes mellitus) in the Andijan region. A comparative analysis of the levels of these microelements in rural and urban populations was conducted. It was found that patients with type 2 diabetes had significantly lower levels of vitamin D and calcium compared to individuals without carbohydrate metabolism disorders. A significant correlation was also identified between reduced zinc levels and the presence of insulin resistance. The results highlight the need for a comprehensive approach to the diagnosis and prevention of carbohydrate metabolism disorders, including monitoring and correcting vitamin D, zinc, and calcium levels.
Downloads
Article Details
Section
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
How to Cite
References
1.Argano C, Mirarchi L, Amodeo S, Orlando V, Torres A, Corrao S. The Role of Vitamin D and Its Molecular Bases in Insulin Resistance, Diabetes, Metabolic Syndrome, and Cardiovascular Disease: State of the Art. Int J Mol Sci. 2023 Oct 23;24(20):15485. doi: 10.3390/ijms242015485.
2. Umar M, Sastry KS, Chouchane AI. Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies. Int J Mol Sci. 2018 May 30;19(6):1618. doi: 10.3390/ijms19061618.
3. Maddaloni E. et al. Vitamin D and diabetes mellitus //Vitamin D in Clinical Medicine. – 2018. – Т. 50. – С. 161-176.
4. Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr. 2011 Sep;65(9):1005-15. doi: 10.1038/ejcn.2011.118.
5. Targher G. et al. Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease //Nutrition, Metabolism and Cardiovascular Diseases. – 2007. – Т. 17. – №. 7. – С. 517-524.
6. Chen X. et al. Association of serum total 25-hydroxy-vitamin D concentration and risk of all-cause, cardiovascular and malignancies-specific mortality in patients with hyperlipidemia in the United States //Frontiers in Nutrition. – 2022. – Т. 9. – С. 971720.
7. Wimalawansa S. J. Non-musculoskeletal benefits of vitamin D //The Journal of steroid biochemistry and molecular biology. – 2018. – Т. 175. – С. 60-81.
8. Teleni L. et al. Clinical outcomes of vitamin D deficiency and supplementation in cancer patients //Nutrition reviews. – 2013. – Т. 71. – №. 9. – С. 611-621.
9. Khademi Z., Hamedi-Shahraki S., Amirkhizi F. Vitamin D insufficiency is associated with inflammation and deregulation of adipokines in patients with metabolic syndrome //BMC Endocrine Disorders. – 2022. – Т. 22. – №. 1. – С. 223.
10. Dianna J. Magliano, Co-chair, Edward J. Boyko, Co-chair; IDF Diabetes Atlas 10th edition scientific committee . Brussels: International Diabetes Federation; 2021.
11. Dong J. Y. et al. Vitamin D intake and risk of type 1 diabetes: a meta-analysis of observational studies //Nutrients. – 2013. – Т. 5. – №. 9. – С. 3551-3562.
12. Нишанова М. С., Айсачева М. О., Захиров А. С. ГИПОВИТАМИНОЗ ВИТАМИНА D3 КАК ПРЕДИКТОР УХУДШЕНИЯ ГЛИКЕМИЧЕСКОГО КОНТРОЛЯ У ЖЕНЩИН С ПРЕДИАБЕТОМ //Медицинский журнал молодых ученых. – 2025. – №. 14 (06). – С. 297-300.
13. Нишанова М. С. и др. ВЗАИМОСВЯЗЬ САХАРНОГО ДИАБЕТА И ОСТЕОПОРОЗА: МЕХАНИЗМЫ, КЛИНИЧЕСКИЕ ПОСЛЕДСТВИЯ И СТРАТЕГИИ ЛЕЧЕНИЯ //INTERDISCIPLINE INNOVATION AND SCIENTIFIC RESEARCH CONFERENCE. – 2024. – Т. 2. – №. 19. – С. 158-162.
14. Afzal S., Bojesen S. E., Nordestgaard B. G. Low 25-hydroxyvitamin D and risk of type 2 diabetes: a prospective cohort study and metaanalysis //Clinical chemistry. – 2013. – Т. 59. – №. 2. – С. 381-391.
15. Lee CJ, Iyer G, Liu Y, Kalyani RR, Bamba N, Ligon CB, Varma S, Mathioudakis N. The effect of vitamin D supplementation on glucose metabolism in type 2 diabetes mellitus: A systematic review and meta-analysis of intervention studies. J Diabetes Complications. 2017 Jul;31(7):1115-1126. doi: 10.1016/j.jdiacomp.2017.04.019.
16. Sharma S, Biswal N, Bethou A, Rajappa M, Kumar S, Vinayagam V. Does Vitamin D Supplementation Improve Glycaemic Control In Children With Type 1 Diabetes Mellitus? - A Randomized Controlled Trial. J Clin Diagn Res. 2017 Sep;11(9):SC15-SC17. doi: 10.7860/JCDR/2017/27321.10645.
17. Ataie-Jafari A. et al. A randomized placebo-controlled trial of alphacalcidol on the preservation of beta cell function in children with recent onset type 1 diabetes //Clinical nutrition. – 2013. – Т. 32. – №. 6. – С. 911-917.
18. Contreras-Bolívar V. et al. Mechanisms involved in the relationship between vitamin D and insulin resistance: impact on clinical practice //Nutrients. – 2021. – Т. 13. – №. 10. – С. 3491.
19. Gysemans C. A. et al. 1, 25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice //Endocrinology. – 2005. – Т. 146. – №. 4. – С. 1956-1964.
20. Park S., Kim D. S., Kang S. Vitamin D deficiency impairs glucose-stimulated insulin secretion and increases insulin resistance by reducing PPAR-γ expression in nonobese Type 2 diabetic rats //The Journal of nutritional biochemistry. – 2016. – Т. 27. – С. 257-265.
21. Melguizo-Rodríguez L, Costela-Ruiz VJ, García-Recio E, De Luna-Bertos E, Ruiz C, Illescas-Montes R. Role of Vitamin D in the Metabolic Syndrome. Nutrients. 2021 Mar 3;13(3):830. doi: 10.3390/nu13030830.
22. Mancuso P, Rahman A, Hershey SD, Dandu L, Nibbelink KA, Simpson RU. 1,25-Dihydroxyvitamin-D3 treatment reduces cardiac hypertrophy and left ventricular diameter in spontaneously hypertensive heart failure-prone (cp/+) rats independent of changes in serum leptin. J Cardiovasc Pharmacol. 2008 Jun;51(6):559-64. doi: 10.1097/FJC.0b013e3181761906.
23. Muoio DM, Newgard CB. Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol. 2008 Mar;9(3):193-205. doi: 10.1038/nrm2327.
24. Lotfy M, Adeghate J, Kalasz H, Singh J, Adeghate E. Chronic Complications of Diabetes Mellitus: A Mini Review. Curr Diabetes Rev. 2017;13(1):3-10. doi: 10.2174/1573399812666151016101622.
25. Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018 Feb;14(2):88-98. doi: 10.1038/nrendo.2017.151.
26. Rooney MR, Fang M, Ogurtsova K, Ozkan B, Echouffo-Tcheugui JB, Boyko EJ, Magliano DJ, Selvin E. Global Prevalence of Prediabetes. Diabetes Care. 2023 Jul 1;46(7):1388-1394. doi: 10.2337/dc22-2376.
27. Blaak EE, Antoine JM, Benton D, Björck I, Bozzetto L, Brouns F, Diamant M, Dye L, Hulshof T, Holst JJ, Lamport DJ, Laville M, Lawton CL, Meheust A, Nilson A, Normand S, Rivellese AA, Theis S, Torekov SS, Vinoy S. Impact of postprandial glycaemia on health and prevention of disease. Obes Rev. 2012 Oct;13(10):923-84. doi: 10.1111/j.1467-789X.2012.01011.x.
28. Zakharova I, Klimov L, Kuryaninova V, Nikitina I, Malyavskaya S, Dolbnya S, Kasyanova A, Atanesyan R, Stoyan M, Todieva A, Kostrova G, Lebedev A. Vitamin D Insufficiency in Overweight and Obese Children and Adolescents. Front Endocrinol (Lausanne). 2019 Mar 1;10:103. doi: 10.3389/fendo.2019.00103
29. Kabadi SM, Lee BK, Liu L. Joint effects of obesity and vitamin D insufficiency on insulin resistance and type 2 diabetes: results from the NHANES 2001-2006. Diabetes Care. 2012 Oct;35(10):2048-54. doi: 10.2337/dc12-0235.
30. Gagnon C. et al. Serum 25-hydroxyvitamin D, calcium intake, and risk of type 2 diabetes after 5 years: results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study) //Diabetes care. – 2011. – Т. 34. – №. 5. – С. 1133-1138.
31. Hu Z, Chen J, Sun X, Wang L, Wang A. Efficacy of vitamin D supplementation on glycemic control in type 2 diabetes patients: A meta-analysis of interventional studies. Medicine (Baltimore). 2019 Apr;98(14):e14970. doi: 10.1097/MD.0000000000014970.
32. Mitri J, Dawson-Hughes B, Hu FB, Pittas AG. Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr. 2011 Aug;94(2):486-94. doi: 10.3945/ajcn.111.011684.
33. Nazarian S, St Peter JV, Boston RC, Jones SA, Mariash CN. Vitamin D3 supplementation improves insulin sensitivity in subjects with impaired fasting glucose. Transl Res. 2011 Nov;158(5):276-81. doi: 10.1016/j.trsl.2011.05.002.
34. Pramono A., Jocken J. W. E., Blaak E. E. Vitamin D deficiency in the aetiology of obesity‐related insulin resistance //Diabetes/metabolism research and reviews. – 2019. – Т. 35. – №. 5. – С. e3146.
35. Alvarez J. A., Ashraf A. Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis //International journal of endocrinology. – 2010. – Т. 2010. – №. 1. – С. 351385.
36. Larrick BM et al. 1, 25-Дигидроксивитамин D регулирует липидный обмен и утилизацию глюкозы в дифференцированных адипоцитах 3T3-L1 //Исследования в области питания. – 2018. – Т. 58. – С. 72-83.
37. Karkeni E. et al. Vitamin D limits inflammation-linked microRNA expression in adipocytes in vitro and in vivo: A new mechanism for the regulation of inflammation by vitamin D //Epigenetics. – 2018. – Т. 13. – №. 2. – С. 156-162.
38. Altieri B, Grant WB, Della Casa S, Orio F, Pontecorvi A, Colao A, Sarno G, Muscogiuri G. Vitamin D and pancreas: The role of sunshine vitamin in the pathogenesis of diabetes mellitus and pancreatic cancer. Crit Rev Food Sci Nutr. 2017 Nov 2;57(16):3472-3488. doi: 10.1080/10408398.2015.1136922.
39. Cade C, Norman AW. Vitamin D3 improves impaired glucose tolerance and insulin secretion in the vitamin D-deficient rat in vivo. Endocrinology. 1986 Jul;119(1):84-90. doi: 10.1210/endo-119-1-84.
40. Zeitz U, Weber K, Soegiarto DW, Wolf E, Balling R, Erben RG. Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J. 2003 Mar;17(3):509-11. doi: 10.1096/fj.02-0424fje.
41. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev. 2008 Oct;29(6):726-76. doi: 10.1210/er.2008-0004
42. Maestro B, Campión J, Dávila N, Calle C. Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J. 2000 Aug;47(4):383-91. doi: 10.1507/endocrj.47.383.
43. Maestro B. et al. Transcriptional activation of the human insulin receptor gene by 1, 25‐dihydroxyvitamin D3 //Cell Biochemistry and Function: Cellular biochemistry and its modulation by active agents or disease. – 2002. – Т. 20. – №. 3. – С. 227-232.
44. Pittas A. G. et al. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults //Diabetes care. – 2007. – Т. 30. – №. 4. – С. 980-986.
45. Bland R. et al. Expression of 25-hydroxyvitamin D3-1α-hydroxylase in pancreatic islets //The Journal of steroid biochemistry and molecular biology. – 2004. – Т. 89. – С. 121-125.
46. REUSCH J. E. B. et al. Regulation of GLUT-4 phosphorylation by intracellular calcium in adipocytes //Endocrinology. – 1991. – Т. 129. – №. 6. – С. 3269-3273.
47. Ryan ZC, Craig TA, Folmes CD, Wang X, Lanza IR, Schaible NS, Salisbury JL, Nair KS, Terzic A, Sieck GC, Kumar R. 1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells. J Biol Chem. 2016 Jan 15;291(3):1514-28. doi: 10.1074/jbc.M115.684399.
48. Jefferson GE, Schnell DM, Thomas DT, Bollinger LM. Calcitriol concomitantly enhances insulin sensitivity and alters myocellular lipid partitioning in high fat-treated skeletal muscle cells. J Physiol Biochem. 2017 Nov;73(4):613-621. doi: 10.1007/s13105-017-0595-8.
49. Krul-Poel YH, Ter Wee MM, Lips P, Simsek S. MANAGEMENT OF ENDOCRINE DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Eur J Endocrinol. 2017 Jan;176(1):R1-R14. doi: 10.1530/EJE-16-0391.
50. Earthman C. P. et al. The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications //International journal of obesity. – 2012. – Т. 36. – №. 3. – С. 387-396.
51. Bajaj S. et al. Vitamin D levels and microvascular complications in type 2 diabetes //Indian journal of endocrinology and metabolism. – 2014. – Т. 18. – №. 4. – С. 537-541.