THE ROLE OF GENETIC FACTORS IN THE EARLY DETECTION OF PREDISPOSITION TO DIABETES
DOI:
https://doi.org/10.55640/Keywords:
Genetic predisposition, diabetes mellitus, early detection, gene variants, risk factors, preventive medicine.Abstract
This study explores the role of genetic factors in the early detection of predisposition to diabetes, with a focus on both Type 1 and Type 2 diabetes mellitus. Genetic markers, including specific gene variants such as TCF7L2, HLA, and FTO, are analyzed to determine their contribution to increased disease risk. Early identification of these markers can help recognize individuals with a higher likelihood of developing diabetes, allowing for timely interventions, lifestyle modification, and preventive strategies. The research highlights the importance of integrating genetic testing into routine screening programs to improve early diagnosis and reduce long-term complications associated with diabetes.
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References
1.American Diabetes Association. (2023). Standards of Medical Care in Diabetes. Diabetes Care, 46(Suppl 1), S1–S200.
2.Prasad, R. B., & Groop, L. (2019). Genetics of Type 2 Diabetes—Pitfalls and Possibilities. Genes, 10(9), 1–21.
3.Barrett, J. C., Clayton, D. G., Concannon, P., et al. (2009). Genome-wide Association Study and Meta-analysis Finds Over 40 Loci Affecting Risk of Type 1 Diabetes. Nature Genetics, 41(6), 703–707.
4.Flannick, J., & Florez, J. C. (2016). Type 2 Diabetes: Genetic Architecture and Lifestyle Interactions. Nature Reviews Endocrinology, 12(1), 6–20.
5.McCarthy, M. I. (2017). Painting a New Picture of Personalized Medicine for Diabetes. Diabetologia, 60(5), 793–799.
6.Grant, S. F. A., & Hakonarson, H. (2008). GWAS and Beyond: The Genetic Architecture of Type 1 Diabetes. Current Opinion in Genetics & Development, 18(3), 221–227.
7.Franks, P. W., & McCarthy, M. I. (2016). Exposing the Exposome to Genome-wide View: Lifestyle–Genetic Interactions in Type 2 Diabetes. PLoS Medicine, 13(3), e1002047.
8.Mahajan, A., Taliun, D., Thurner, M., et al. (2018). Fine-mapping Type 2 Diabetes Loci to Single-Variant Resolution Using High-Density Imputation. Nature Genetics, 50(11), 1505–1513.
9.Todd, J. A. (2010). Etiology of Type 1 Diabetes. Immunity, 32(4), 457–467.
10.Hu, F. B. (2011). Globalization of Diabetes: The Role of Diet, Lifestyle, and Genes. Diabetes Care, 34(6), 1249–1257.
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