THE ROLE OF AZOXY FUNCTIONAL GROUPS IN ENHANCING ACARICIDAL ACTIVITY OF AROMATIC COMPOUNDS.
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Abstract
Azoxy functional groups (-N=N(O)-) have gained considerable attention in agrochemical research due to their ability to modulate biological activity in aromatic compounds. This study investigates the influence of azoxy moieties on the acaricidal efficacy of synthetic aromatic derivatives against selected mite species. A series of azoxybenzene-based compounds were synthesized and evaluated for their biological activity using standardized bioassay methods. The structure–activity relationship (SAR) analysis revealed that the presence of azoxy linkages significantly enhances acaricidal potency compared to their azo or nitro analogs, likely due to improved electron distribution and target affinity. Spectroscopic (FTIR, NMR) and chromatographic (GC-MS) techniques confirmed the purity and structure of synthesized compounds. The findings support the hypothesis that azoxy functionalization contributes to increased bioefficacy and selectivity, making such derivatives potential candidates for next-generation eco-friendly acaricides.
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