PHYSIOLOGICAL ROLES OF THE LIVER AND PANCREAS: INTEGRATED METABOLIC, SECRETORY, AND REGULATORY FUNCTIONS IN HUMAN HOMEOSTASIS

Authors

  • Azimboyeva Zarnigor Qudrat kizi Asia International University

DOI:

https://doi.org/10.55640/

Keywords:

liver physiology, pancreas physiology, hepatic glucose metabolism, glycogen synthesis, gluconeogenesis, bile acids, CYP7A1, insulin secretion, GSIS, glucagon, GLP-1, incretin axis, hepatopancreatic axis, metabolic homeostasis, NAFLD

Abstract

The liver and pancreas are anatomically adjacent, developmentally related, and functionally inseparable organs that together orchestrate the central metabolic, digestive, endocrine, and detoxification functions essential to human homeostasis. The liver performs over 500 distinct physiological functions including glucose buffering, lipoprotein metabolism, plasma protein synthesis, bile acid production, and xenobiotic biotransformation. The pancreas provides both exocrine digestive enzyme secretion and endocrine glucose-insulin regulation through its acinar and islet cell compartments.

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References

[1] Hall, J. E., & Hall, M. E. (2020). Guyton and Hall Textbook of Medical Physiology (14th ed.). Elsevier. ISBN: 978-0-323-59712-8.

[2] Rui, L. (2014). Energy metabolism in the liver. Comprehensive Physiology, 4(1), 177–197. https://doi.org/10.1002/cphy.c130024

[3] Rinella, M. E., Lazarus, J. V., Ratziu, V., Francque, S. M., Sanyal, A. J., Kanwal, F., ... & Loomba, R. (2023). A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology, 78(6), 1966–1986. https://doi.org/10.1097/HEP.0000000000000520

[4] Trauner, M., Claudel, T., Fickert, P., Moustafa, T., & Wagner, M. (2010). Bile acids as regulators of hepatic lipid and glucose metabolism. Digestive Diseases, 28(1), 220–224. https://doi.org/10.1159/000282091

[5] Pandol, S. J. (2011). The Exocrine Pancreas. Morgan & Claypool Life Sciences. https://doi.org/10.4199/C00051ED1V01Y201112ISP031

[6] Rorsman, P., & Ashcroft, F. M. (2018). Pancreatic β-cell electrical activity and insulin secretion: Of mice and men. Physiological Reviews, 98(1), 117–214. https://doi.org/10.1152/physrev.00008.2017

[7] Drucker, D. J. (2006). The biology of incretin hormones. Cell Metabolism, 3(3), 153–165. https://doi.org/10.1016/j.cmet.2006.01.004

[8] Meier, J. J., & Nauck, M. A. (2010). Is the diminished incretin effect in type 2 diabetes just an epiphenomenon of impaired β-cell function? Diabetes, 59(5), 1117–1125. https://doi.org/10.2337/db09-1899

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Published

2026-04-08

Issue

Vol. 5 No. 4 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

PHYSIOLOGICAL ROLES OF THE LIVER AND PANCREAS: INTEGRATED METABOLIC, SECRETORY, AND REGULATORY FUNCTIONS IN HUMAN HOMEOSTASIS. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(4), 518-525. https://doi.org/10.55640/

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