THE ROLE OF NEUROENDOCRINE DISORDERS IN THE DEVELOPMENT OF LONG-TERM OUTCOMES AFTER TRAUMATIC BRAIN INJURY IN CHILDREN

Authors

  • Kuldasheva Ya.M. Andijan State Medical Institute

DOI:

https://doi.org/10.55640/

Keywords:

Traumatic brain injury, children, neuroendocrine disorders, hypothalamic–pituitary axis, long-term outcomes, pediatric endocrinology

Abstract

Traumatic brain injury (TBI) in childhood is associated with a wide range of long-term neurological, cognitive, and somatic consequences. In recent years, increasing attention has been directed toward neuroendocrine disorders as a key factor influencing delayed and persistent complications after TBI. Damage to hypothalamic–pituitary structures may lead to hormonal dysregulation, which significantly affects growth, metabolism, neurocognitive development, and quality of life in pediatric patients. This article analyzes the role of neuroendocrine disorders in the formation of long-term outcomes after traumatic brain injury in children. The study highlights pathophysiological mechanisms, clinical implications, and the importance of early diagnosis and long-term endocrine monitoring.

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References

1.Schneider, H. J., Kreitschmann-Andermahr, I., Ghigo, E., Stalla, G. K., & Agha, A. (2007). Hypothalamopituitary dysfunction following traumatic brain injury. JAMA, 298(12), 1429–1438.

2.Agha, A., & Thompson, C. J. (2006). High risk of hypopituitarism after traumatic brain injury. Journal of Clinical Endocrinology & Metabolism, 91(6), 2105–2111.

3.Tanriverdi, F., et al. (2015). Pituitary dysfunction after traumatic brain injury: Clinical perspectives. Endocrine Reviews, 36(3), 305–342.

4.Acerini, C. L., et al. (2013). Endocrine sequelae of childhood traumatic brain injury. Archives of Disease in Childhood, 98(7), 567–572.

5.Kokshoorn, N. E., et al. (2010). Long-term endocrine consequences of traumatic brain injury. Pituitary, 13(4), 273–279.

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Published

2026-01-19

Issue

Vol. 5 No. 01 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

THE ROLE OF NEUROENDOCRINE DISORDERS IN THE DEVELOPMENT OF LONG-TERM OUTCOMES AFTER TRAUMATIC BRAIN INJURY IN CHILDREN. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(01), 1246-1248. https://doi.org/10.55640/

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