THE ROLE OF MICROORGANISMS IN STROKE DEVELOPMENT: MECHANISMS AND CLINICAL SIGNIFICANCE
Main Article Content
Abstract
Stroke is one of the chronic and severe neurological disorders that occurs as a result of impaired blood supply to the central nervous system. In recent years, the role of microorganisms in the development of stroke has been widely studied. Research indicates that bacteria, viruses, and other microorganisms can influence the central nervous system through various mechanisms. This article discusses the mechanisms by which microorganisms contribute to stroke development, their effects on immunological responses, inflammatory processes, and their association with the formation of atherosclerosis. Additionally, the relationship between microbial infections and human genetic predisposition is analyzed. The research methodology includes the review of scientific literature, clinical observations, and epidemiological data. The results demonstrate that microorganisms may be considered risk factors for stroke, especially in cases of infections caused by Streptococcus, Chlamydia pneumoniae, and herpesviruses. The article also discusses the potential for stroke prevention through anti-inflammatory therapy and the use of antibiotics. In conclusion, the role of microorganisms in stroke development is complex and largely linked to the immune system, suggesting promising directions for the development of new diagnostic and therapeutic strategies in the future.
Downloads
Article Details
Section
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
How to Cite
References
1.Iadecola, C., & Anrather, J. (2011). The immunology of stroke: from mechanisms to translation. Nature Medicine, 17(7), 796–808.
2.Sessa, R., et al. (2018). Infections and risk of stroke: systematic review. Stroke, 49(3), 619–627.
3.Elkind, M.S.V., et al. (2010). Chlamydia pneumoniae infection and risk of stroke. Neurology, 74(17), 1422–1430.
4.Harms, H., & Schon, M. (2019). Microbial contribution to cerebrovascular disease. Journal of Neuroinflammation, 16(1), 142.
5.Grau, A.J., et al. (2005). Infectious burden and atherosclerosis. Stroke, 36(5), 1083–1088.
6.Zeng, L., et al. (2016). Herpes simplex virus and stroke risk: a meta-analysis. Journal of Neurology, 263(5), 880–888.
7.Liu, L., et al. (2017). Endothelial dysfunction in infection-related stroke. Frontiers in Neurology, 8, 647.
8.Frostegård, J. (2013). Inflammation, infection, and atherosclerosis. Journal of Internal Medicine, 273(5), 405–418.
9.Wright, C.L., et al. (2012). Microbiota, immunity and stroke. Brain, Behavior, and Immunity, 26(6), 810–818.
10.Elkind, M.S.V. (2016). Infectious agents and stroke: evidence and mechanisms. Stroke, 47(4), 893–900.