Age-Specific Therapeutic Efficacy of Aloe Vera Gel Extract in Alloxan-Induced Diabetes in Male Mice
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Abstract
The therapeutic potential of Aloe vera gel extract in managing diabetes has garnered significant interest, particularly concerning its efficacy across different age groups. This study investigates the age-specific effects of ethanolic extract of Aloe vera gel on alloxan-induced diabetes in male mice, categorized into young, adult, and old groups. Alloxan was used to induce diabetes in mice, and the efficacy of Aloe vera gel extract was assessed through various biochemical and physiological parameters.
Male mice from each age group were administered with the ethanolic extract of Aloe vera gel for a specified duration, following which their blood glucose levels, insulin sensitivity, and markers of oxidative stress were evaluated. The results revealed that Aloe vera gel extract effectively reduced blood glucose levels and improved insulin sensitivity across all age groups, but the degree of efficacy varied with age. Young mice showed the most pronounced therapeutic response, followed by adult and older mice, suggesting that age influences the efficacy of Aloe vera treatment.
The study highlights that while Aloe vera gel extract exhibits beneficial effects in managing alloxan-induced diabetes, the therapeutic efficacy is age-dependent. These findings underscore the need for age-specific considerations in the application of Aloe vera as a therapeutic agent and contribute valuable insights into its potential as a complementary treatment for diabetes. Further research is warranted to explore the underlying mechanisms of age-related differences in therapeutic response and to optimize Aloe vera-based interventions for diverse age groups.
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