PHARMACOGENETICS: GENETIC BASIS OF DRUG RESPONSE
DOI:
https://doi.org/10.55640/Keywords:
Pharmacogenetics, Drug response, Genetic variations, Personalized medicine, Gene-drug interactionAbstract
Pharmacogenetics is a branch of science that studies how genetic variations influence an individual’s response to drugs. Differences in genes can affect the absorption, metabolism, distribution, and excretion of medications, leading to variations in efficacy and the risk of adverse effects. Understanding these genetic factors enables healthcare professionals to predict patient-specific drug responses and optimize therapy. The development of personalized medicine relies on pharmacogenetic insights to improve treatment outcomes, minimize side effects, and enhance patient safety. As research advances, pharmacogenetics plays a crucial role in tailoring drug therapy according to genetic profiles, thus transforming conventional approaches to medication management.
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References
1.IngelmanSundberg, M. “Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future.” Trends in Pharmacological Sciences, 2004.
2.Evans, W. E., & McLeod, H. L. “Pharmacogenomics — drug disposition, drug targets, and side effects.” New England Journal of Medicine, 2003.
3.Crews, K. R., Hicks, J. K., Pui, C.-H., Relling, M. V., & Evans, W. E. “Pharmacogenomics and individualized medicine: translating science into practice.” Clinical Pharmacology & Therapeutics, 2012.
4.A Review of the Important Role of CYP2D6 in Pharmacogenomics. PubMed+1
5.The Influence of Pharmacogenetics on the Clinical Relevance of Pharmacokinetic Drug–Drug Interactions. MDPI
6.Pharmacogenetics of Second Generation Antihistamines: A Systematic Review. @WalshMedical
7.Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes. BioMed Central
8.Voriconazole Therapy and CYP2C19 Genotype — NCBI Bookshelf. НЦБИ
9.Impact of Pharmacogenomics in Clinical Practice. MDPI
10.Association of CYP2C19 and CYP2D6 Poor and Intermediate Metabolizer Status With Antidepressant and Antipsychotic Exposure: Metaanalysis. JAMA Network
11.Application and Utility of Pharmacogenetics in the Clinical Laboratory. avensonline.org
12.Review: Rare CYP2C19 and CYP2D6 Variants in Pharmacogenetics. Frontiers
13.Pharmacogenetics: (a historic review) — Um.edu.mt publication. L-Università ta' Malta
14.Frontiers in Psychiatry – Genetic Variation and DrugMetabolizing Enzymes Review. Frontiers
15.Pharmacogenetics of CYP- (CYP2D6, CYP2C19) — CME presentation by ARUP (University of Utah).
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