PHARMACOLOGICAL AND NON-PHARMACOLOGICAL METHODS IN THE TREATMENT OF HYPERTENSION
Main Article Content
Abstract
Hypertension is a leading global health problem and a major risk factor for cardiovascular diseases, stroke, renal failure, and premature mortality. Effective management requires a combination of pharmacological and non-pharmacological interventions. Pharmacological treatment includes antihypertensive medications such as diuretics, beta-blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors (ACEIs), and angiotensin II receptor blockers (ARBs), which lower blood pressure and reduce the risk of complications. Treatment choice depends on patient characteristics, comorbidities, and blood pressure levels.
Non-pharmacological methods play a vital complementary role in hypertension management. Lifestyle modifications such as dietary changes (DASH diet, reduced sodium intake, increased potassium), regular physical activity, weight control, moderation of alcohol consumption, smoking cessation, and stress management have been shown to lower blood pressure effectively. These approaches not only enhance the effectiveness of medications but also reduce the need for high drug dosages.
The integration of pharmacological and non-pharmacological approaches provides the best outcomes, preventing disease progression and improving quality of life. Patient education, adherence to treatment, and long-term monitoring are critical for success. This article explores the principles and evidence-based practices of both pharmacological and lifestyle-based management of hypertension, highlighting the importance of a holistic, patient-centered approach.
Downloads
Article Details
Section

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
How to Cite
References
1.James, P.A., et al. (2014). 2014 Evidence-based guideline for the management of high blood pressure in adults (JNC 8). JAMA, 311(5), 507–520.
2.Williams, B., et al. (2018). 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J, 39(33), 3021–3104.
3.Lewington, S., et al. (2002). Age-specific relevance of usual blood pressure to vascular mortality. Lancet, 360(9349), 1903–1913.
4.Appel, L.J., et al. (1997). A clinical trial of the effects of dietary patterns on blood pressure (DASH). N Engl J Med, 336(16), 1117–1124.
5.Neter, J.E., et al. (2003). Influence of weight reduction on blood pressure: a meta-analysis. Hypertension, 42(5), 878–884.
6.World Health Organization (2021). Sodium intake for adults and children. WHO.
7.Whelton, P.K., et al. (2018). 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/… Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults. Hypertension, 71(6), e13–e115.
8.Ettehad, D., et al. (2016). Blood pressure lowering for prevention of cardiovascular disease and death. Lancet, 387(10022), 957–967.
9.Chobanian, A.V., et al. (2003). Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure (JNC 7). Hypertension, 42(6), 1206–1252.
10.He, F.J., & MacGregor, G.A. (2010). Reducing population salt intake worldwide: From evidence to implementation. Prog Cardiovasc Dis, 52(5), 363–382.
11.Mancia, G., & Grassi, G. (2014). The autonomic nervous system and hypertension. Circ Res, 114(11), 1804–1814.
12.Carey, R.M., & Whelton, P.K. (2018). Prevention, detection, evaluation, and management of high blood pressure in adults: Synopsis of the 2017 ACC/AHA guideline. Ann Intern Med, 168(5), 351–358.
13.Brook, R.D., et al. (2013). Beyond medications and diet: Alternative approaches to lowering blood pressure. J Clin Hypertens, 15(7), 467–471.
14.Dickinson, H.O., et al. (2006). Lifestyle interventions to reduce raised blood pressure: systematic review. J Hypertens, 24(2), 215–233.
15.Julius, S., et al. (2006). Outcomes in hypertensive patients at high cardiovascular risk treated with valsartan or amlodipine. Lancet, 367(9513), 2023–2031.
16.Gupta, R., & Yusuf, S. (2019). Challenges and solutions in the management of hypertension in low- and middle-income countries. Nat Rev Cardiol, 16(10), 619–633.