MORPHOFUNCTIONAL ANALYSIS OF NASAL HISTOLOGY IN HEALTHY HUMANS
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Abstract
This study addresses the lack of detailed baseline data on the normal histological and functional characteristics of the human nasal mucosa, which plays a critical role in air filtration, humidification, and temperature regulation, by establishing reference values for epithelial thickness, glandular density, and vascularization. Furthermore, understanding the normal distribution of mucins and epithelial markers such as cytokeratin and MUC5AC provides a foundation for future molecular and diagnostic research. Given the increasing incidence of respiratory diseases linked to environmental pollution and climate change, a thorough assessment of nasal morphology under healthy conditions is particularly timely and clinically important.
This study therefore fills a significant gap by providing a detailed morphofunctional profile of the healthy human nasal mucosa, contributing to the development of diagnostic standards and improving our understanding of nasal physiology and pathology.
The nasal cavity plays a vital role in the respiratory system by performing critical functions such as air filtration, humidification, and warming. These functions are closely related to the histological structure of the nasal mucosa, including the epithelium, submucosal glands, and vascular components. This study aims to conduct a detailed morphofunctional analysis of nasal histology in healthy adult humans. Nasal mucosal biopsy samples were collected from 20 healthy volunteers and examined using histological, histochemical, and immunohistochemical methods. Morphometric measurements of epithelial thickness, gland density, and vascularization were performed. The findings highlight the structural characteristics of healthy nasal mucosa and provide a baseline for future pathological comparisons. This research contributes valuable insights into nasal tissue functionality and its relevance for clinical diagnostics and treatment.
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References
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