EVALUATING THE EFFICACY OF BETA-BLOCKER THERAPY IN CHILDREN WITH HEART FAILURE

Authors

  • Mukhammadkhonov Abdulfaizkhon Shamsuddinkhon ugli Department of Propaedeutics of Children's Diseases and Polyclinic Pediatrics,Andijan State Medical Institute

DOI:

https://doi.org/10.55640/

Keywords:

pediatric heart failure, beta-blockers, carvedilol, treatment efficacy, left ventricular dysfunction, cardiomyopathy, neurohormonal blockade, ventricular remodeling.

Abstract

English: Heart failure (HF) in children, while less common than in adults, is a serious condition with significant morbidity and mortality, often resulting from congenital heart defects or cardiomyopathy. The pathophysiology involves sustained neurohormonal activation, particularly of the sympathetic nervous system, which leads to progressive cardiac remodeling and dysfunction. In adult HF, beta-adrenergic receptor blockers (beta-blockers) are a cornerstone of therapy, proven to improve cardiac function and survival. However, the pediatric HF population is heterogeneous, and the underlying causes differ significantly from adults. Therefore, directly extrapolating adult treatment guidelines is not always appropriate. Investigating the specific efficacy, safety, and optimal use of beta-blockers in children with HF is crucial for developing evidence-based pediatric treatment protocols and improving clinical outcomes in this vulnerable population. This expanded review seeks to provide a deeper analysis of the existing evidence, challenges in clinical application, and future research directions.

 

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References

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Published

2025-10-11

Issue

Vol. 4 No. 9 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

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Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

EVALUATING THE EFFICACY OF BETA-BLOCKER THERAPY IN CHILDREN WITH HEART FAILURE. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(9), 355-360. https://doi.org/10.55640/

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