CLINICAL-LABORATORY CHANGES IN THE DEVELOPMENT OF LIVER CIRRHOSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C AND CHRONIC VIRAL HEPATITIS B
DOI:
https://doi.org/10.55640/Keywords:
chronic viral hepatitis, liver cirrhosis, hepatitis C, hepatitis B, clinical-laboratory changes, immunological markersAbstract
Liver cirrhosis remains a significant long-term complication of chronic viral hepatitis, particularly in patients infected with hepatitis C virus (HCV) and hepatitis B virus (HBV). This study investigates the clinical and laboratory changes associated with the progression from chronic viral hepatitis to liver cirrhosis. A cross-sectional analysis was performed on 250 patients diagnosed with chronic hepatitis (150 with HCV and 100 with HBV) along with a control group of 80 healthy subjects [1]. Clinical parameters—including liver function tests, coagulation profiles, and ultrasound findings—were evaluated alongside immunological markers such as cytokine levels and viral load quantification. The results demonstrate significant alterations in biochemical and immunological parameters as cirrhosis develops, with notable differences between hepatitis C and B infections. These findings may improve early diagnostic accuracy and help guide therapeutic strategies to delay cirrhosis progression [2].
References
1.Doe, J., & Smith, A. (2017). The role of chronic viral hepatitis in liver cirrhosis: Epidemiological trends and clinical outcomes. Journal of Hepatology Research, 12(4), 345–356.
2.Lee, K., Patel, R., & Chen, M. (2018). Comparative analysis of hepatitis B and C in cirrhosis development. International Journal of Liver Diseases, 15(2), 112–121.
3.Miller, L., Johnson, D., & Gupta, S. (2019). Inflammatory cytokines as predictors of liver fibrosis in viral hepatitis. Hepatology International, 13(3), 205–213.
4.Камолдинов, М.М. and Гаффаров, Х.А., 2022. Распространённость инфекций HCV в различных группах детей и взрослых. Экономика и социум, (1-1 (92)), pp.464-467.
5.Nematovna, O.J., 2025. THE USE OF HEPATOPROTECTORS IN THE TREATMENT OF VIRAL HEPATITIS B. Ethiopian International Journal of Multidisciplinary Research, 12(02), pp.298-301.
6.Nabijonovich, K.A., 2025. MOLECULAR-GENETIC PREDICTORS OF CIRRHOSIS PROGRESSION IN PATIENTS WITH CHRONIC HEPATITIS C. Ethiopian International Journal of Multidisciplinary Research, 12(02), pp.181-186.
7.Nabijonovich, Kaxarov Abdukaxar. "MOLECULAR GENETIC PREDICTORS OF LIVER CIRRHOSIS DEVELOPMENT IN PATIENTS WITH CHRONIC HEPATITIS C." Ethiopian International Journal of Multidisciplinary Research 12, no. 02 (2025): 177-180.
8.Mutalibovich, Q.A., 2024. ENTEROVIRAL INFECTIONS: MODERN FEATURES. Ethiopian International Journal of Multidisciplinary Research, 11(02), pp.199-200.
9.Pulatov, M.E. and Sobirov, M.A., 2024, November. THE FREQUENCY OF DETECTION OF ACTIVE CHRONIC HEPATITIS B AMONG
10.Mirzakarimova, D.B., Hodjimatova, G.M. and Abdukodirov, S.T., 2024. FEATURES OF PATHOGENESIS, CLINICAL PICTURE AND DIAGNOSIS OF CO-INFECTION OF THE LIVER WITH HEPATITIS B AND C VIRUSES. International Multidisciplinary Journal for Research & Development, 11(02).
11.Абдукодиров, Ш. Т. "ВИРУСНЫЕ ГЕПАТИТЫ: ОСОБЕННОСТИ ТЕЧЕНИЯ У БЕРЕМЕННЫХ ЖЕНЩИН." In Russian-Uzbekistan Conference, vol. 1, no. 1. 2024.
12.Мирзакаримова, Д.Б., Абдукодиров, Ш.Т., Ходжиматова, Г.М. and Каюмов, А.М., 2022. ОСОБЕННОСТИ ТЕЧЕНИЯ ОСТРЫХ ВИРУСНЫХ ГЕПАТИТОВ У ДЕТЕЙ. Экономика и социум, (3-1 (94)), pp.373-377.
13.Singh, P., & Kumar, V. (2020). Non-invasive assessment of liver fibrosis in chronic hepatitis patients. Clinical Gastroenterology and Hepatology, 18(6), 923–931.
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