STUDY OF THE ANTIHYPOXIC ACTIVITY OF A COMPOSITION OF L-CARNITINE AND SUCCINIC ACID IN EXPERIMENTAL MODELS OF HYPOXIA

Authors

  • Abdugaffarov A.A., Tulyaganov B.S. Tashkent Pharmaceutical Institute, Tashkent

DOI:

https://doi.org/10.55640/

Keywords:

hypoxia condition, sodium nitrite, dry extract, L-carnitine, amber acid, normobaric and hemic hypoxia, protection coefficient.

Abstract

The antihypoxic properties of a composition based on l-carnitine and succinic acid were studied in comparison with the drug Mildronate, manufactured by JSC Grindex, Latvia, in normobaric and hemic hypoxia models in 48 male white outbred mice.

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References

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2. Лукьянова, Л.Д. Современные проблемы адаптации к гипоксии. Сигнальные механизмы и их роль в системной регуляции / Л.Д. Лукьянова // Патологическая физиология и экспериментальная терапия. - 2011. - №1. - С.3-19.

3. Москаленко С. В., Шахматов И. И, Бондарчук Ю. А, Улитина О. М, Алексеева О. В Влияние однократного и многократного воздействия гипоксической гипоксии сильной интенсивности на состояние системы гемостаза у крыс. Сибирский научный медицинский журнал, том 38, № 1, 2018, С 32-37

4. Биомедицинское(доклиническое) изучение антигипоксической активности лекарственных средств., Методические рекомендации. Под редакцией д.м.н., профессора Н.Н. Каркищенко. Москва 2017, С-28

5. Krähenbuhl, S. L-Carnitine and physical performance. In Proceedings of the Symposium on L-Carnitine, a ‘Vitamin-Like Substance’, Zermatt, Switzerland, 28 April–1 May 2000.

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Published

2026-06-12

Issue

Vol. 5 No. 6 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

STUDY OF THE ANTIHYPOXIC ACTIVITY OF A COMPOSITION OF L-CARNITINE AND SUCCINIC ACID IN EXPERIMENTAL MODELS OF HYPOXIA. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(6), 907-910. https://doi.org/10.55640/

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