IL23R GENE POLYMORPHISM IN APLASTIC ANEMIA IN THE UZBEK POPULATION

Authors

  • Akhmedova Zukhra Bakhtiyorovna , Akhmedova Fotima Bakhtiyorovna RANCH University, Ma’mun University

DOI:

https://doi.org/10.5281/zenodo.20430324

Keywords:

aplastic anemia, IL23R, cytokines, genetic polymorphism, Th17 cells, Uzbek population, pancytopenia.

Abstract

This article examines the role of interleukin-23 receptor (IL23R) genetic polymorphism in the pathogenesis of acquired aplastic anemia (AA). The aim of the study was to investigate the distribution of allele and genotype frequencies of the rs11209026 (G/A) locus and their association with the risk of developing and the severity of pancytopenia in patients of Uzbek nationality. A comparative analysis of 86 AA cases and 98 controls was conducted. RT-PCR revealed a predominance of the G/G genotype in all groups. Despite the lack of a statistically significant association (P > 0.05), the obtained data contribute to a better understanding of the population genetics of blood diseases in Central Asia.

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References

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11.Akhmedova Zukhra Bakhtiyarovna, senior Lecturer at RANCH University, number: +99894 726 87 88.

12.Akhmedova Fotima Bakhtiyorovna, acting Associate Professor of Mamun University, number: +99899 741 98 88.

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Published

2026-05-28

Issue

Vol. 5 No. 5 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

IL23R GENE POLYMORPHISM IN APLASTIC ANEMIA IN THE UZBEK POPULATION. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(5), 1880-1884. https://doi.org/10.5281/zenodo.20430324

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