HISTOPATHOLOGICAL PATTERNS OF GASTRIC INJURY ASSOCIATED WITH MAGNESIUM, IRON, ZINC AND SELENIUM DEFICIENCY

Authors

  • Abosov Azizbek Salim ugli Independent researcher at the Bukhara State Medical Institute named after Abu Ali ibn Sino

DOI:

https://doi.org/10.55640/

Keywords:

stomach, gastric injury, histopathology, magnesium, iron, zinc, selenium, microelement deficiency, gastric mucosa.

Abstract

This article presents an experimental histopathological assessment of gastric injury associated with magnesium, iron, zinc and selenium deficiency. The study was performed on 3- and 6-month-old white outbred rats. The gastric mucosa was evaluated under isolated deficiency of Mg, Fe, Zn and Se, as well as under combined Mg+Fe+Zn+Se deficiency. The results showed that each type of microelement deficiency produced a specific pattern of gastric injury. Magnesium deficiency was mainly associated with reduced secretory and regenerative activity, iron deficiency with damage to parietal cells, zinc deficiency with impairment of the epithelial barrier, and selenium deficiency with dystrophic and inflammatory changes. Combined deficiency caused the most severe injury, involving the epithelium, gastric glands, lamina propria, vascular bed and proliferative activity of the mucosa.

Downloads

Download data is not yet available.

References

1.Laine L., Takeuchi K., Tarnawski A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology. 2008;135(1):41–60.

2.Wallace J.L. Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn’t the stomach digest itself? Physiological Reviews. 2008;88(4):1547–1565.

3.Prasad A.S. Discovery of human zinc deficiency: its impact on human health and disease. Advances in Nutrition. 2013;4(2):176–190.

4.Skrovanek S., DiGuilio K., Bailey R., et al. Zinc and gastrointestinal disease. World Journal of Gastrointestinal Pathophysiology. 2014;5(4):496–513.

5.Nettleford S.K., Prabhu K.S. Selenium and selenoproteins in gut inflammation — A review. Antioxidants. 2018;7(3):36.

Downloads

Published

2026-05-07

Issue

Vol. 5 No. 5 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

HISTOPATHOLOGICAL PATTERNS OF GASTRIC INJURY ASSOCIATED WITH MAGNESIUM, IRON, ZINC AND SELENIUM DEFICIENCY. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(5), 492-494. https://doi.org/10.55640/

Similar Articles

31-40 of 276

You may also start an advanced similarity search for this article.