MODULATION OF MYOCARDIAL COLLAGEN REMODELING BY MILK THISTLE AND SAFFLOWER EXTRACTS AFTER CARBON MONOXIDE EXPOSURE

Authors

  • Mamedova Guletar Telman kizi Independent researcher, Bukhara State Medical Institute named after Abu Ali ibn Sino, Republic of Uzbekistan, Bukhara

DOI:

https://doi.org/10.55640/

Keywords:

carbon monoxide, myocardium, collagen remodeling, fibrosis, Van Gieson staining, milk thistle, safflower, phytocorrection.

Abstract

Carbon monoxide exposure causes tissue hypoxia and may lead to structural remodeling of the myocardium. One of the important manifestations of chronic myocardial injury is excessive collagen accumulation and development of interstitial fibrosis. The aim of this study was to evaluate collagen remodeling in the myocardium of white outbred rats after carbon monoxide exposure and to assess the corrective effect of milk thistle and safflower extracts. The study was performed on 6- and 18-month-old white outbred rats. Collagen fibers were detected using Van Gieson staining and assessed by digital morphometry.

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References

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Published

2026-05-05

Issue

Vol. 5 No. 5 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

MODULATION OF MYOCARDIAL COLLAGEN REMODELING BY MILK THISTLE AND SAFFLOWER EXTRACTS AFTER CARBON MONOXIDE EXPOSURE. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(5), 372-375. https://doi.org/10.55640/

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