CHANGES IN BLOOD COAGULATION PARAMETERS FOLLOWING CHRONIC MUMIYO ADMINISTRATION IN DOGS

Abstract

The present study evaluated the effects of chronic oral administration of mumiyo on the blood coagulation system in dogs. Five clinically healthy adult dogs of both sexes were administered mumiyo at a dose of 300 mg/kg body weight once daily. Blood samples were collected before treatment and on days 3, 5, and 6 of administration to assess coagulation parameters. Blood clotting time, plasma recalcification time, plasma tolerance to heparin, heparin time, thrombin time, coagulation factors II and V, and fibrinolytic activity were analyzed. Data were expressed as mean ± SD, and statistical comparisons were performed using Student’s paired t-test. Mumiyo administration produced significant, time-dependent changes in hemostasis. Blood clotting time, plasma recalcification time, heparin time, plasma tolerance to heparin, and thrombin time were significantly prolonged compared with baseline values. Coagulation factors II and V showed significant increases at later stages of the experiment, while fibrinolytic activity was significantly altered throughout the study period. Despite partial compensatory changes in coagulation factors, the overall effect of mumiyo was characterized by a pronounced hypocoagulant and anticoagulant action.