INFLUENCE OF MUMIYO ON HEMOSTASIS DURING INDOMETHACIN-INDUCED PROSTAGLANDIN SUPPRESSION

Abstract

This study aimed to evaluate the effect of mumiyo on blood coagulation under conditions of inhibited prostaglandin synthesis using indomethacin. Experiments were conducted on dogs, and blood coagulation was assessed by thromboelastography. Baseline coagulation parameters were recorded prior to drug administration. Indomethacin was administered intravenously at a dose of 5 mg/kg to inhibit prostaglandin synthesis. After the development of its effect, mumiyo extract was injected intravenously at a dose of 50 mg/kg. Thromboelastographic parameters were measured at various time intervals following each intervention. Indomethacin produced time-dependent alterations in thromboelastographic indices, characterized by transient procoagulant changes. Some parameters showed partial recovery within 30–60 minutes after administration. Subsequent administration of mumiyo modified these effects, resulting in a tendency toward normalization of coagulation parameters and indicating a mild hypocoagulant influence. Inhibition of prostaglandin synthesis by indomethacin leads to transient changes in blood coagulation. Mumiyo administration under these conditions exerts a moderate regulatory effect on hemostasis, suggesting that its anticoagulant action is at least partially independent of prostaglandin-mediated mechanisms.