CHANGE OF ANTIOXIDANT SYSTEM IN DIABETIC MODEL RAT LIVER CELLS AND ITS CORRECTION WITH COMPLEX COMPOUNDS
DOI:
https://doi.org/10.55640/Keywords:
Diabetes, metformin, taurine, Schiff's base, alloxan, antioxidant, lipid peroxidation, liver, alanine aminotransferase, aspartate aminotransferase, malondialdehydeAbstract
Diabetes is the most common disease associated with metabolic disorders. Diabetes mellitus is characterized by dysfunction of pancreatic beta cells. Taurine is a β-amino acid that is widely distributed in mammalian tissues and is not involved in protein synthesis. The purpose of this study was to study the effect of a complex combination of taurine and Schiff's base derivative on the antioxidant system in the liver of model rats with diabetes. 12 male white rats were divided into 4 groups: Control, diabetic (QD), diabetic treated with Metformin (QD+Metformin), diabetic treated with Taurine and Schiff base (QD+Tau/Schiff base). Rats were injected subcutaneously for 3 days at a dose of 140 mg/kg of alloxan to induce diabetes. It was observed that blood glucose content and daily water intake increased during two weeks, as well as body weight decreased. The 3rd and 4th groups with diabetes were treated with metformin and complex combination for 1 week. Treatment with taurine reduces the decrease in liver catalase and protein content and the increased levels of glutamyl transferase (Gt), alanine aminotransferase (AlAt) and aspartate aminotransferase (AsAt) in the blood. In addition, it was found to reduce the level of malondialdehyde (MDA), a secondary metabolite of lipids in the liver and blood. These results indicated that taurine and schiff base complex are effective in alleviating diabetes by reducing oxidative stress and blood glucose levels.
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