CLINICAL INTERRELATIONSHIPS BETWEEN GASTROESOPHAGEAL REFLUX DISEASE AND BRONCHIAL ASTHMA IN CHILDREN
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Abstract
The article describes the clinical features and possible pathogenetic relationships of gastroesophageal reflux disease (GERD) in children with bronchial asthma (BA). One of the factors contributing to the development of GERD in patients with BA is chronic hyperergic-associated inflammation in the fundal and cardiac regions of the stomach. A total of 65 children aged 6 to 17 years with varying degrees of asthma severity were examined. Clinical-anamnestic, instrumental (24-hour pH monitoring, spirometry), and laboratory methods were used. The results indicate a strong association between severe asthma and GERD, which represents an unfavorable prognostic sign, as it increases the likelihood of transformation from mild to severe asthma. Signs of GERD were detected in 43 (66.2%) children with asthma, more often in cases of uncontrolled disease. Patients with both BA and GERD showed reduced forced expiratory volume in one second (FEV₁) and peak expiratory flow, as well as more frequent nocturnal symptoms. The findings confirm the need for screening and correction of reflux disorders in children with asthma to optimize therapy and improve disease control.
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