CHOICE OF ANTIPLATELET THERAPY FOR PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITHOUT PCI

Authors

  • Bakaev I.A. Alfraganus University, Tashkent, Uzbekistan

DOI:

https://doi.org/10.55640/

Keywords:

acute myocardial infarction, non-PCI, antiplatelet therapy, dual antiplatelet therapy, conservative management.

Abstract

 Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. While percutaneous coronary intervention (PCI) is the preferred reperfusion strategy, a substantial proportion of patients are managed conservatively without PCI due to logistical, anatomical, or clinical reasons. Optimal antiplatelet therapy is critical in this population to prevent recurrent ischemic events and reduce mortality. This review summarizes current evidence on the choice of antiplatelet therapy in patients with AMI managed without PCI, including dual antiplatelet therapy (DAPT) options, the duration of therapy, and considerations for bleeding risk. Recent randomized controlled trials and guideline recommendations are discussed.

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References

1.Roth GA, et al. Global Burden of Cardiovascular Diseases and Risk Factors, 2020. Circulation. 2021;143:1746–1760.

2.Bangalore S, et al. Management of AMI patients not undergoing PCI. J Am Coll Cardiol. 2020;76:1809–1820.

3.Levine GN, et al. 2020 ACC/AHA Guideline for the Management of Patients with AMI. Circulation. 2020;142:e1–e31.

4.Ibanez B, et al. 2020 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2020;41:3495–3676.

5.Steg PG, et al. Antiplatelet therapy in non-PCI STEMI: a review. Lancet. 2018;392:1937–1946.

6.Chen ZM, et al. COMMIT: Clopidogrel in AMI without PCI. Lancet. 2005;366:1607–1621.

7.Montalescot G, et al. CLARITY-TIMI 28: Clopidogrel and thrombolysis. N Engl J Med. 2001;345:494–502.

8.Wallentin L, et al. PLATO trial: Ticagrelor in non-PCI patients. N Engl J Med. 2009;361:1045–1057.

9.Wiviott SD, et al. TRITON-TIMI 38: Prasugrel in ACS. N Engl J Med. 2007;357:2001–2015.

10.Collet JP, et al. 2023 ACC/AHA Update on AMI without PCI. J Am Coll Cardiol. 2023;81:1440–1472.

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Published

2025-12-28

How to Cite

CHOICE OF ANTIPLATELET THERAPY FOR PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITHOUT PCI. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(11), 3343-3345. https://doi.org/10.55640/

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