CLINICAL AND MORPHOLOGICAL STAGES OF LICHEN SCLEROSUS ET ATROPHICUS AND IMMUNOHISTOCHEMICAL MARKERS OF PROGRESSION

Authors

  • Omasharifa binti Jamal Po Kursk State Medical University Candidate of Medical Sciences (PhD), Associate Professor Department of Obstetrics and Gynecology (Postgraduate Education)

DOI:

https://doi.org/10.55640/

Keywords:

lichen sclerosus, morphogenesis, immunohistochemistry, CD31, VEGF, CD95, angiogenesis, apoptosis, squamous cell carcinoma.

Abstract

Lichen sclerosus et atrophicus is characterized by a staged restructuring of the epidermis and dermis, including an early inflammatory interface dermatitis and a late scleroatrophic stage. Immunohistochemical (IHC) markers of endothelial activation and hypoxia (CD31, VEGF) and apoptosis (CD95/Fas) reflect the dynamics of morphogenesis and can be used for early detection of the risk of squamous cell carcinoma of the vulva and penis. The review systematizes current data on the histopathological patterns of LS, vascular and apoptotic progression mechanisms, as well as differential diagnosis with morphea and precancerous lesions.

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References

1.De Luca D.A., Atzori L., Benato F. Et al. Lichen sclerosus: The 2023 update // Dermatology and Therapy. 2023. Vol. 13. P. 1–28. DOI:10.1007/s13555-023-00864-9.

2.Corazza M., Borghi A., Gafà R. Et al. Vulvar Lichen Sclerosus from Pathophysiology to Therapeutic Approaches // Biomedicines. 2021. Vol. 9(8). 950. DOI:10.3390/biomedicines9080950.

3.Attili V.R., Attili S.K. Clinical and histopathological spectrum of genital lichen sclerosus in 133 cases, focus on pre-sclerotic disease // Indian J Dermatol Venereol Leprol. 2022. Vol. 88. P. 1–8.

4.Mihara Y., Kawaguchi M., Hattori T. Lichen sclerosus et atrophicus: a histological and immunohistochemical study // J Cutan Pathol. 1994. Vol. 21(6). P. 553–561. PMID:7864656.

5.Zarina K.Z., Al-Mutairi N., Sharma A. Expression of Ki-67, Nestin, VEGF, CD34 and apoptotic markers in lichen sclerosus // Cancers. 2022. Vol. 11(1). 7. DOI:10.3390/cancers11010007.

6.Yang H., Almadani N., Thompson E.F. et al. Classification of vulvar SCC and precursor lesions by p16/p53 immunohistochemistry // Modern Pathology. 2023. Vol. 36(6). 100145. DOI: 10.1016/j.modpat.2023.100145.

7.Shim W.H., Jwa S.W., Song M. Et al. Diagnostic usefulness of dermatoscopy in differentiating lichen sclerosus et atrophicus from morphea // JAAD. 2012. Vol. 66(4). P. 690–696. DOI: 10.1016/j.jaad.2011.01.019.

8.Errichetti E., Stinco G. Dermoscopy of morphea and cutaneous lichen sclerosus: clinicopathological correlation // Dermatology. 2017. Vol. 233(5). P. 430–437. DOI:10.1159/000485169.

9.Hussein M.R.A., Abdel-Rahman M., Zaki N. Immunohistological analysis of dermal dendritic cells and microvessel density in lichen sclerosus // Actas Dermosifiliogr. 2021. Vol. 112(9). P. 787–794. DOI:10.1016/j.ad.2021.03.018.

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Published

2025-12-19

Issue

Vol. 4 No. 11 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

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Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

CLINICAL AND MORPHOLOGICAL STAGES OF LICHEN SCLEROSUS ET ATROPHICUS AND IMMUNOHISTOCHEMICAL MARKERS OF PROGRESSION. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(11), 2485-2488. https://doi.org/10.55640/

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