CLINICAL AND MORPHOLOGICAL STAGES OF LICHEN SCLEROSUS ET ATROPHICUS AND IMMUNOHISTOCHEMICAL MARKERS OF PROGRESSION
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Abstract
Lichen sclerosus et atrophicus is characterized by a staged restructuring of the epidermis and dermis, including an early inflammatory interface dermatitis and a late scleroatrophic stage. Immunohistochemical (IHC) markers of endothelial activation and hypoxia (CD31, VEGF) and apoptosis (CD95/Fas) reflect the dynamics of morphogenesis and can be used for early detection of the risk of squamous cell carcinoma of the vulva and penis. The review systematizes current data on the histopathological patterns of LS, vascular and apoptotic progression mechanisms, as well as differential diagnosis with morphea and precancerous lesions.
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