CHANGES OF HETEROPOLYSACCHARIDES IN ONTOGENESIS AND DISEASES

Authors

  • Azamatova Ruxshona Hoshimjon kizi,Axmatjonov Qudratillo Mashrabjon ugli Kokand University, Andijan Branch 2nd-year student of the General Medicine program,Kokand University, Andijan Branch

DOI:

https://doi.org/10.55640/

Keywords:

Heteropolysaccharides, glycosaminoglycans (GAGs), hyaluronan, chondroitin sulfate, dermatan sulfate, keratan sulfate, heparan sulfate, heparin, proteoglycans, extracellular matrix (ECM).

Abstract

 Heteropolysaccharides are a group of complex polysaccharides that participate in the structural, functional, and signaling mechanisms of living organism tissues. During ontogenesis, the quantity, composition, and macromolecular properties of these substances change significantly. In diseases, particularly in metabolic and hereditary pathologies, disturbances in heteropolysaccharide metabolism lead to morphofunctional insufficiency of tissues and organs. This article provides an in-depth scientific analysis of changes in heteropolysaccharides during ontogenesis, their molecular biological roles, metabolic disorders observed in diseases, as well as their diagnostic and therapeutic significance.

Downloads

Download data is not yet available.

References

1.Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (2017). Molecular Biology of the Cell (6th ed.). Garland Science.

2.Varki, A., Cummings, R. D., Esko, J. D., Freeze, H. H., Stanley, P., Bertozzi, C., & Etzler, M. E. (2015). Essentials of Glycobiology (3rd ed.). Cold Spring Harbor Laboratory Press.

3.Iozzo, R. V., & Schaefer, L. (2015). Proteoglycans in health and disease: Novel regulatory signaling mechanisms. Matrix Biology, 42, 1–3.

4.Lawrence, R., Olson, S. K., Steele, R. E., & Wang, L. (2008). Evolutionary origins and structural diversity of vertebrate heparan sulfate. Journal of Biological Chemistry, 283(11), 7124–7134.

5.Neufeld, E. F., & Muenzer, J. (2014). The mucopolysaccharidoses. In The Metabolic and Molecular Bases of Inherited Disease (pp. 3421–3452). McGraw-Hill.

6.Muenzer, J. (2011). Overview of the mucopolysaccharidoses. Rheumatology, 50(Suppl 5), v4–v12.

7.Theocharis, A. D., Skandalis, S. S., Tzanakakis, G. N., & Karamanos, N. K. (2016). Proteoglycans in health and disease: Novel roles in malignancy and inflammation. Advances in Pharmacology, 79, 281–295.

8.Roughley, P. J., & Mort, J. S. (2014). The role of cartilage proteoglycans in osteoarthritis. Nature Reviews Rheumatology, 10(9), 531–541.

9.Bishop, J. R., Schuksz, M., & Esko, J. D. (2007). Heparan sulfate proteoglycans fine-tune mammalian physiology. Nature, 446, 1030–1037.

10.Lindahl, U., Couchman, J., Kimata, K., & Esko, J. D. (2017). Proteoglycans and sulfated glycosaminoglycans. In Essentials of Glycobiology (3rd ed.). Cold Spring Harbor Laboratory Press.

Downloads

Published

2025-12-17

Issue

Vol. 4 No. 11 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

CHANGES OF HETEROPOLYSACCHARIDES IN ONTOGENESIS AND DISEASES. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(11), 2210-2213. https://doi.org/10.55640/

Similar Articles

1-10 of 29

You may also start an advanced similarity search for this article.