UTERINE FIBROIDS IN WOMEN: HISTOLOGICAL STRUCTURE AND PATHOGENESIS
DOI:
https://doi.org/10.55640/Keywords:
Uterine fibroids, leiomyoma, histology, pathogenesis, hormonal influence, extracellular matrix, genetic factors, angiogenesis.Abstract
Uterine fibroids, also known as leiomyomas, are the most common benign tumors of the female reproductive system. This study focuses on their histological structure and pathogenesis, examining the cellular composition, extracellular matrix characteristics, and molecular mechanisms underlying fibroid development. The review highlights the role of hormonal influences, particularly estrogen and progesterone, genetic mutations, growth factors, and angiogenesis in the formation and progression of uterine fibroids. Understanding these factors is crucial for improving diagnostic methods and developing targeted therapies. The study also emphasizes the clinical implications of fibroid growth, including reproductive issues, abnormal uterine bleeding, and pelvic pain.
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