ANTI-INFLAMMATORY ACTIVITY OF HYDROXYTYROSOL: AN EXPERIMENTAL ANALYSIS BASED ON NF-ΚB, COX-2, AND CYTOKINE MODULATION

Authors

  • Khakimov Muhammadi Khamidjon ugli Department of Biological Chemistry, Andijan State Medical Institute, Uzbekistan, Andijan

DOI:

https://doi.org/10.55640/

Keywords:

Hydroxytyrosol; inflammation; NF-κB; COX-2; cytokines; TNF-α; IL-1β; IL-6; iNOS; anti-inflammatory; polyphenols; antioxidant; MAPK; inflammation modulation; bioactive compound.

Abstract

 In this article, the anti-inflammatory activity of hydroxytyrosol was experimentally analyzed based on NF-κB, COX-2, and cytokine modulation. The results of the study demonstrated that hydroxytyrosol exerts multi-directional effects on inflammatory signals and mediators: nuclear translocation of NF-κB is inhibited, COX-2 expression decreases, and the production of cytokines such as TNF-α, IL-1β, and IL-6 is significantly reduced. In addition, HT reduces oxidative stress and activates endogenous antioxidant systems. These findings provide a scientific basis for the use of hydroxytyrosol as an effective nutraceutical and therapeutic agent in inflammation-related diseases.

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References

1. Spiridovich E. V. et al. Analysis of secondary metabolites in the bark of lilac species (Syringa L.) introduced in the Central Botanical Garden of the National Academy of Sciences of Belarus // Vestnik Pharmatcii. - 2018. - No. 4 (82). - P. 28-37.

2. Sokurenko M. S., Bessonov V. V., Solovieva N. L. Hydroxytyrosol - a natural antioxidant of olive oil // Nutrition Issues. - 2015. - Vol. 84. - No. S5. - P. 75-75.

3. KRYSIN A. P. et al. Cardioprotective effect of p-thyrosol in the acute period of cardiovascular and cerebral ischemia // Chemistry for Sustainable Development. – 2019. – Vol. 27. – No. 4. – P. 365-372.

4. Zaporozhskiy A. A., Mohammad A. T. Towards the creation of gerodietetic nutrition products with immunoprotective properties // Modern problems of food safety. Proceedings of the international scientific conference. Editorial board: Stekolnikov A. A. – 2020. – P. 37.

5. Shilov V. et al. Anti-ischemic effect of isoliquiritigenin and a combination of hydroxytyrosol with cis-aconitate, cytosine and amino acids // Science and innovation. – 2016. – Vol. 5. – No. 159. – P. 64-66.

6. Storozhok N. M. et al. Antioxidant effect of structural analogs of tyrosol, the active substance of Rhodiola rosea // Butlerov communications. – 2011. – T. 24. – No. 3. – pp. 105-108.

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Published

2025-11-19

Issue

Vol. 4 No. 10 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

ANTI-INFLAMMATORY ACTIVITY OF HYDROXYTYROSOL: AN EXPERIMENTAL ANALYSIS BASED ON NF-ΚB, COX-2, AND CYTOKINE MODULATION. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(10), 1437-1440. https://doi.org/10.55640/

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