STUDY OF MOLECULAR-GENETIC FACTORS IN THE ETIOPATHOGENETIC COURSE OF CHRONIC DISEASES OF THE TEMPOROMANDIBULAR JOINTS AND DEVELOPMENT OF A PREVENTION ALGORITHM

Authors

  • Davronbek Dadajonov Murodil ogli Student of the Faculty of Medicine, Andijan Branch of Kokand University 2nd-year student of the "General Medicine" program

DOI:

https://doi.org/10.55640/

Keywords:

Temporomandibular joint, chronic diseases, etiopathogenesis, molecular-genetic factors, genetic predisposition, prevention algorithm, personalized medicine, early diagnosis, joint dysfunction, biomarkers.

Abstract

This article explores the role of molecular-genetic factors in the etiopathogenetic course of chronic temporomandibular joint (TMJ) disorders. Recent studies have shown that TMJ pathologies are not only the result of mechanical or traumatic influences, but also closely associated with genetic predisposition. Therefore, this research focuses on the identification of genetic markers, their impact on disease progression, and the scientific justification for developing personalized preventive strategies. The paper also proposes an innovative prevention algorithm aimed at early detection and management of chronic TMJ diseases. The results of the study are of significant scientific and practical value for the implementation of personalized approaches in modern medicine.

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References

1.Scrivani, S. J., Keith, D. A., & Kaban, L. B. (2008). Temporomandibular disorders. The New England Journal of Medicine, 359(25), 2693-2705.

2.Wang, M., Hu, Y., & Yang, J. (2015). Role of IL-1β and TNF-α in temporomandibular joint inflammation and cartilage degradation. Journal of Oral Pathology & Medicine, 44(10), 803-809.

3.Yuan, G., Meng, J., & Zhang, W. (2016). Genetic polymorphisms of MMP family and temporomandibular joint osteoarthritis. International Journal of Oral Science, 8(4), 255-261.

4.Li, X., Zhang, L., & Zhao, Q. (2019). COL2A1 mutations and their association with TMJ disorders. Molecular Genetics & Genomic Medicine, 7(6), e00706.

5.Gauer, R. L., & Semidey, M. J. (2015). Diagnosis and treatment of temporomandibular disorders. American Family Physician, 91(6), 378-386.

6.Kim, S. H., Park, K. H., & Choi, Y. S. (2020). Epigenetic regulation in temporomandibular joint disorders: DNA methylation profiles in pain-related genes. Pain Research and Management, 2020, Article ID 9462371.

7.Takatori, R., Yamamoto, T., & Kawakami, Y. (2021). Oxidative stress and mitochondrial dysfunction in chronic TMJ diseases. Oxidative Medicine and Cellular Longevity, 2021, 8816247.

8.Zhou, Y., Li, J., & Liu, H. (2022). Genome-wide association study identifies novel loci for temporomandibular joint disorders. Scientific Reports, 12, 1589.

9.Al-Khotani, A., Al-Melh, M., & Al-Dabbagh, N. (2018). Prevalence of temporomandibular disorders among adolescents: The role of genetic predisposition. European Journal of Orthodontics, 40(5), 548-555.

10.UNESCO Science Report. (2021). Genomics and bioinformatics in public health: Strategies for musculoskeletal disorders. UNESCO Publishing.

11.Manfredini, D., Piccotti, F., Ferronato, G., & Guarda-Nardini, L. (2011). Age peaks of different RDC/TMD diagnoses in a patient population. Journal of Oral Rehabilitation, 38(3), 190-196.

12.Schiffman, E., Ohrbach, R., Truelove, E., Look, J., Anderson, G., Goulet, J. P., ... & Dworkin, S. F. (2014). Diagnostic criteria for temporomandibular disorders (DC/TMD) for clinical and research applications: Recommendations of the International RDC/TMD Consortium Network. Journal of Oral & Facial Pain and Headache, 28(1), 6-27.

13.Emamifar, A., & Sadr, S. (2017). Molecular pathways involved in TMJ osteoarthritis pathogenesis. Current Rheumatology Reviews, 13(1), 18-26.

14.Silva, D. F., & Oliveira, F. (2019). The role of inflammatory mediators in temporomandibular disorders: A systematic review. Rheumatology International, 39(9), 1503-1513.

15.Zhang, L., & Chen, X. (2020). Advances in the genetics of temporomandibular joint disorders. Frontiers in Genetics, 11, 587428.

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Published

2025-09-30

Issue

Vol. 4 No. 8 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

STUDY OF MOLECULAR-GENETIC FACTORS IN THE ETIOPATHOGENETIC COURSE OF CHRONIC DISEASES OF THE TEMPOROMANDIBULAR JOINTS AND DEVELOPMENT OF A PREVENTION ALGORITHM. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(8), 802-808. https://doi.org/10.55640/

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