HELICOBACTER PYLORI AND GASTRIC CANCER: PROSPECTS OF A PERSONALIZED APPROACH

Authors

  • Azimjon Yo‘ldoshev Zafarjon ugli Kokand University, Andijan Branch, Medical Faculty

DOI:

https://doi.org/10.55640/

Keywords:

Helicobacter pylori, chronic gastritis, intestinal metaplasia, glandular atrophy, gastric cancer, CagA, VacA, p53 mutation, dysplasia, epigenetic changes, modern therapy, urease enzyme, probiotics, inflammatory mediators, non-invasive diagnostics.

Abstract

This scientific thesis thoroughly examines the pathological changes induced by Helicobacter pylori infection in the gastric mucosa, including their clinical manifestations, morphological stages, and its role in the development of gastric cancer. Modern diagnostic methods—both invasive and non-invasive—are discussed in detail, alongside effective treatment strategies such as bismuth-based quadruple therapy, combination antibiotic regimens, and adjunctive probiotic use. The scientific and practical relevance of this work lies in the fact that early detection and treatment of H. pylori infection play a crucial role in preventing gastric cancer among the population.

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References

1. Yo‘ldoshev T.T., Egamova S.T. Pathogenesis and Clinical Presentation of Diseases. — Tashkent: Tibbiyot Publishing, 2020. — 480 pages.

2. Azizov A.A., Teshaboyev B.Yu. Gastroenterology: Clinical and Practical Guide. — Tashkent: Ilm Ziyo, 2021. — 356 pages.

3. Sattorov O‘.X., Abdurahmonova R.A. Molecular Biology and Genetics. — Tashkent: Fan va texnologiya, 2019. — 400 pages.

4. Bobojonov E.T. Fundamentals of Modern Oncology. — Tashkent: Tibbiyot, 2022. — 300 pages.

5. World Health Organization (WHO). Helicobacter pylori and Gastric Cancer. https://www.who.int

6. Mayo Clinic. Helicobacter pylori (H. pylori) Infection – Diagnosis and Treatment. https://www.mayoclinic.org

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Published

2025-07-21

Issue

Vol. 4 No. 6 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

HELICOBACTER PYLORI AND GASTRIC CANCER: PROSPECTS OF A PERSONALIZED APPROACH. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(6), 336-337. https://doi.org/10.55640/

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