EVALUATION OF ACUTE TOXICITY PROPERTIES OF YARROW AND COMMON OAK PLANT EXTRACTS

Authors

  • Makhmudov L.U.,Rahimova M.A.,Yo’ldosheva Sh.S,Karayeva N.Y.,Qurambayeva D.G. ²Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, Tashkent, Republic of Uzbekistan,¹Tashkent Pharmaceutical Institute, Tashkent, Republic of Uzbekistan

DOI:

https://doi.org/10.55640/

Keywords:

Acute toxicity, plant extract, white laboratory mice, LD₅₀, toxicity class, evaluation indicators.

Abstract

Nowadays, preparations made from medicinal plant raw materials are being studied with great interest by the global community compared to synthetic biologically active substances. Due to the side effects of synthetic drugs considered suitable for treating chronic diseases, people around the world prefer plant-based preparations. Traditional medicinal plants can provide new compounds that counter the high cost and toxicity of available drugs, especially for rural populations in developing countries [1].

This article presents data on the acute toxicity properties of an extract sample obtained from Achillea millefolium (yarrow) and Quercus robur (common oak), studied at the Pharmacology and Screening Laboratory of the Institute of Bioorganic Chemistry of the Academy of Sciences of Uzbekistan.

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References

1.Internet information: https://doi.org/10.1016/j.joad.2015.06.010

2.Qurambayeva D. Karayeva N.Y. Study of tincture preparation technology from the aerial parts of Achillea millefolium and oak bark; 82nd Scientific Society of Students. Tashkent–2025.

3.H. X. Xolmatov, O’.A.Ahmedov Pharmacognosy Part I and II; Tashkent, 2007.

4. OECD (2001) Guideline for testing of chemicals. Acute Oral Toxicity Fixed Dose Procedure No 420 Руководящий документ ОЭСР Test № 420 << Acute Oral Toxicity - Fixed Dose Procedure».

5.Manual for Preclinical Drug Research. Part One, edited by A.N. Mironov. Moscow: Grif i K, 2012. – 944 pages.

6.Karayeva N.Y., Rahmonova G.G., Abdullajona N.G'., Raimova K.V. Preclinical general and specific toxicology study of Glabtan dry extract from rhus glabra. International journal of artificial intelligence (issn: 2692-5206) Volume 04 Issue 03 2024 P.277-282.

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Published

2025-06-17

Issue

Vol. 4 No. 5 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

EVALUATION OF ACUTE TOXICITY PROPERTIES OF YARROW AND COMMON OAK PLANT EXTRACTS. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(5), 695-697. https://doi.org/10.55640/

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