SOME REACTIONS OF Α-HYDROXY- AND Α- DIMETHYLAMINOFORMYLIDINE – 2,3-POLYMETHYLENE-3,4-DIHYDROQUINAZOLIN-4-ONES
DOI:
https://doi.org/10.55640/Keywords:
α-hydroxy- and α- dimethylaminoformylidene – 2,3-polymethylene-3,4-dihydroquinazolin-4-one, acylation , amination , transamination , enamine , acetone cyanohydrin , bromination .Abstract
The reactions of acylation , amination and transamination of α-oxy- and α- dimethylaminoformylidene – 2,3-polymethylene-3,4-dihydroquinazolin-4-ones were studied and the corresponding acyl -and aminoformylidene production ( enamines ).
Their interaction with acetone cyanohydrin yielded α- dimethylamino (oxy)cyanomethyl-2,3-trimethylene-3,4-dihydroquinazolin-4-one which hydrolyzed to amino acids ( oxyacids ).
Bromination of α- dimethylamino – 2,3-trimethylene-3,4-dihydroquinazolin-4-one produces α-bromo- α- formyl 2,3-trimethylene-3,4-dihydroquinazolin-4-one.
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