MUTANT VIRUSES AS A FACTOR IN CHANGING THE CLINICAL PRESENTATION OF INFECTIOUS DISEASES IN THE CONTEXT OF A GLOBAL PANDEMIC

Authors

  • Muhammadova Mumina Baxodirovna Andijan Branch of Kokand University Faculty of Medicine Program: General Medicine, 2nd Year, Group 24-37

DOI:

https://doi.org/10.55640/

Keywords:

Mutant viruses, infectious diseases, clinical presentation, pandemic, vaccine efficacy, viral genetics.

Abstract

Mutant viruses represent a significant factor influencing the clinical presentation of infectious diseases in the context of a global pandemic. Recent viral mutations have altered disease progression, symptom severity, and transmissibility, creating new challenges for public health systems. The emergence of mutant strains can reduce immune responses, diminish vaccine efficacy, and necessitate reassessment of existing therapeutic strategies. Therefore, continuous monitoring of viral genetic changes, epidemiological surveillance, and updates in preventive measures are crucial for effective pandemic management [1,2].

References

1.Alquraan L., et al. Mutations of SARSCoV2 and their impact on disease traits, transmissibility, and virulence: a comprehensive analysis. Front. Med. 2023; Mutational changes explain viral behavior and clinical implications.

2.Malik J.A., et al. The SARSCoV2 mutations versus vaccine effectiveness: Evolution of variants and challenges for immunization strategies. Vaccines & Therapeutics 2022; Highlights mutation impact on vaccines.

3.Faraji N., et al. Mutational dynamics of SARSCoV2: Impact on future vaccine strategies and clinical presentation. Heliyon 2024; Discusses VOCs and clinical outcomes.

4.Islam M.A., et al. A review of SARSCoV2 variants and vaccines: genomic structure, mutation effects, and clinical concerns. Tsinghua Sci. Technol. 2023; Presents mutation and clinical connection.

5.Mahilkar S., et al. SARSCoV2 variants: Impact on biological and clinical characteristics, disease presentation and management. Front. Med. 2022; Focus on clinical outcomes with viral variants.

6.MendiolaPastrana I.R., et al. SARSCoV2 Variants and Clinical Outcomes: A systematic review of how mutations alter disease severity and presentation. Life 2022; Variantspecific clinical outcomes.

7.Carabelli A.M., et al. SARSCoV2 variant biology: immune escape and increased transmissibility in VOCs. Nat. Rev. Microbiol. 2023; Highly cited foundational review on variants of concern.

8.Tabatabaei S.N., et al. SARSCoV2 and Coronaviruses: Nonspike mutations and their influence on transmissibility and severity. MDPI 2025; Examines diverse mutation impacts beyond spike protein.

9.Hadizadeh N., et al. Appraisal of SARSCoV2 mutations and vaccination implications. Springer. 2022; Explores mutation effects on infection severity and immunity.

10.Young M., et al. COVID19: Virology, variants and vaccines — implications for clinical presentation and global control. BMJ Med. 2022; Review of variant features and clinical impact.

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Published

2026-02-16

How to Cite

MUTANT VIRUSES AS A FACTOR IN CHANGING THE CLINICAL PRESENTATION OF INFECTIOUS DISEASES IN THE CONTEXT OF A GLOBAL PANDEMIC. (2026). International Journal of Political Sciences and Economics, 5(02), 255-260. https://doi.org/10.55640/

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