GENETIC FACTORS IN THE DEVELOPMENT OF PULMONARY SYNDROME (COR PULMONALE)

Authors

  • G.M. Kutlikova Andijan Branch of Kokand University. Faculty of Medicine.
  • Kh.R. Rustamovna Andijan Branch of Kokand University. Faculty of Medicine.

DOI:

https://doi.org/10.55640/

Keywords:

Keywords: Pulmonary heart disease, cor pulmonale, genetic factors, pulmonary hypertension, chronic obstructive pulmonary disease, BMPR2, genetic predisposition

Abstract

Abstract. This study evaluates the profound role of genetic susceptibility in the pathogenesis and progression of pulmonary heart disease, clinically identified as cor pulmonale. Traditional paradigms have heavily emphasized environmental and acquired factors, yet contemporary molecular evidence demonstrates a strong genetic basis underlying individual variations in disease severity. This article provides a comprehensive analysis of genetic predispositions in conditions associated with chronic obstructive pulmonary disease and pulmonary arterial hypertension. Particular emphasis is placed on the regulatory functions of SERPINA1, the angiotensin-converting enzyme gene, interleukin-6, and the serotonin transporter gene. Furthermore, the transforming growth factor-beta and bone morphogenetic protein signaling pathways are extensively reviewed, with a focus on the BMPR2 gene. Through a synthesis of recent clinical and molecular genetic data, the critical importance of gene-environment interactions in the complex pathogenesis of cor pulmonale is delineated.

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References

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Published

2026-06-11 — Updated on 2026-06-15

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Issue

Vol. 5 No. 6 (2026): Journal of Multidisciplinary Sciences and Innovations

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Articles

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Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

GENETIC FACTORS IN THE DEVELOPMENT OF PULMONARY SYNDROME (COR PULMONALE). (2026). Journal of Multidisciplinary Sciences and Innovations, 5(6), 839-844. https://doi.org/10.55640/ (Original work published 2026)

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