THE RELEVANCE OF IMPROVING SCIENTIFIC RESEARCH ON THE TREATMENT AND PREVENTION OF PARKINSON'S DISEASE

Abstract

Parkinson's disease (PD) is a neurological disorder that worsens over time and causes both motor and non-motor symptoms that significantly lower quality of life. PD has been treated with pharmaceuticals, mostly levodopa. However, their long-term efficacy is sometimes limited by adverse effects such dyskinesias and motor irregularities. The entire landscape of neurosurgical therapies has changed in the last several decades due to advances and developments. This narrative review examines clinical research on gene therapy, neurosurgery, and other contemporary PD treatments. Three additional papers were extracted from other databases, and 47 studies were found in the PubMed search. The most well-established neurosurgical method, deep brain stimulation (DBS), has compelling evidence that it can alleviate motor symptoms. Although focused ultrasound (FUS) offers a noninvasive alternative, most research on it still lacks long-term evidence. Although they are still in the early stages of clinical development, gene therapy approaches such as AAV2-hAADC and ProSavin have demonstrated early-phase safety and efficacy. In the future, robotic surgery and more advanced imaging methods may be crucial to PD-related surgery. Newer neurosurgical and gene therapy techniques are expanding the choices for treating Parkinson's disease. Although the current results are encouraging, more extensive, controlled trials are needed to demonstrate long-term safety and effectiveness. This review is very significant, according to research in the literature, because it addresses numerous rehabilitation therapy for Parkinson's disease patients in a single document for the first time. This review article's objective is to compare the efficacy of two different therapy interventions for Parkinson's disease patients.